罗汉松酸
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- CAS号:
- 5947-49-9
- 英文名:
- PODOCARPIC ACID
- 英文别名:
- Nsc 231784;PODOCARPIC ACID;Einecs 227-706-3;Podocarpic acid 98%;Podocarpic acid, >99%;12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID;Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (van) (8ci);1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID;inhibit,Podocarpic acid,Transient receptor potential channels,TRP Channel,Inhibitor;1,2,3,4,4a,9,10,10aβ-Octahydro-6-hydroxy-1,4aα-dimethyl-1α-phenanthrenecarboxylic acid
- 中文名:
- 罗汉松酸
- 中文别名:
- 罗汉松酸, >99%
- CBNumber:
- CB2309721
- 分子式:
- C17H22O3
- 分子量:
- 274.35
- MOL File:
- 5947-49-9.mol
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罗汉松酸化学性质
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熔点:
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193-196 °C (lit.)
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比旋光度:
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20546 +165° (c = 4 in abs ethanol)
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沸点:
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449.6±45.0 °C(Predicted)
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密度:
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1.182±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: ≥ 100 mg/mL (364.50 mM)
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酸度系数(pKa):
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4.66±0.40(Predicted)
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旋光性 (optical activity):
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[α]20/D +133°, c = 4 in ethanol
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Merck:
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13,7625
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罗汉松酸性质、用途与生产工艺
Podocarpic acid 是一种天然产物，为 TRPA1 的激活剂，具有多种功效。
Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells.
Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca
2+
flux, which is significantly reduces when the Ca
2+
-impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels.
罗汉松酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-N2318 | Podocarpic acid | | 5 mg | 350元 |
| 2024/01/25 | HY-N2318 | 罗汉松酸
Podocarpic acid | 5947-49-9 | 10mg | 500元 |
罗汉松酸
生产厂家
全球有 34家供应商
罗汉松酸国内生产厂家
5947-49-9, 罗汉松酸 相关搜索:
- Complex Molecules
- Chiral Building Blocks
- Asymmetric Synthesis
- 高端化学
- Complex Molecules
- Asymmetric Synthesis
- Chiral Building Blocks
- 罗汉松酸, >99%
- 5947-49-9
- inhibit,Podocarpic acid,Transient receptor potential channels,TRP Channel,Inhibitor
- Podocarpic acid, >99%
- 12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID
- 1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID
- PODOCARPIC ACID
- Podocarpic acid 98%
- Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (van) (8ci)
- Nsc 231784
- Einecs 227-706-3
- 1,2,3,4,4a,9,10,10aβ-Octahydro-6-hydroxy-1,4aα-dimethyl-1α-phenanthrenecarboxylic acid
- (1R)-1,4aα-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aβ-octahydrophenanthrene-1α-carboxylic acid
- [1S,(+)]-1,2,3,4,4a,9,10,10aα-Octahydro-6-hydroxy-1,4aβ-dimethyl-1β-phenanthrenecarboxylic acid
- (1S)-1,4aβ-Dimethyl-6-hydroxy-1,2,3,4,4a,9,10,10aα-octahydrophenanthrene-1β-carboxylic acid
- (1S)-1,2,3,4,4aβ,9,10,10aα-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid
- 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy -1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))- (9CI)
- 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S,4aS,10aR)-
- 1,4-alpha-Dimethyl-6-hydroxy-1,2,3,4-alpha-9,10,10-alpha-octahydro-1-phenanthrenecarboxylicacid
- (1S,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid