1404091-23-1
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- CAS号:
- 1404091-23-1
- 英文名:
- NucPE1
- 英文别名:
- NucPE1;NUCPE1?, >98%;Nuclear Peroxy Emerald 1;Nuclear Peroxy Emerald 1, >98%;3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9'-xanthene]-1-one;Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- 中文名:
- 1404091-23-1
- 中文别名:
- 化合物 T19042
- CBNumber:
- CB23339684
- 分子式:
- C29H30BNO5
- 分子量:
- 483.36
- MOL File:
- 1404091-23-1.mol
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1404091-23-1化学性质
-
沸点:
-
643.5±55.0 °C(Predicted)
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-
密度:
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1.26±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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3.40±0.20(Predicted)
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1404091-23-1性质、用途与生产工艺
NucPE1 (Nuclear Peroxy Emerald 1) 是核定位荧光过氧化氢探针, 其特异性定位于细胞核,没有附加的靶向部分。
NucPE1 features two major visible region absorptions (λ
abs
=468 nm, ε=27,300 M
-1
cm
-1
; λ
abs
=490 nm, ε=26,000 M
-1
cm
-1
) and a weak emission (λ
em
=530 nm, Φ=0.117). Reaction of NucPE1 with H
2
O
2
triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M
-1
cm
-1
) with enhanced emission (λ
em
=530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like
C. clegans
, where it can respond to subcellular changes in H
2
O
2
fluxes.
NucPE1 maintains the ability to selectively target nuclei
in vivo
. NucPE1 imaging reveals a reduction in nuclear H
2
O
2
levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools.
1404091-23-1
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/01/25 | HY-101859 | 1404091-23-1 NucPE1 | 1404091-23-1 | 1mg | 1500元 |
2024/01/25 | HY-101859 | 1404091-23-1 NucPE1 | 1404091-23-1 | 5mg | 4500元 |
1404091-23-1, 1404091-23-1 相关搜索:
- 化合物 T19042
- 1404091-23-1
- Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9'-xanthene]-1-one
- Nuclear Peroxy Emerald 1
- NUCPE1?, >98%
- Nuclear Peroxy Emerald 1, >98%
- NucPE1