1404091-23-1
| 中文名称 | 1404091-23-1 |
|---|---|
| 中文同义词 | 化合物 T19042 |
| 英文名称 | NucPE1 |
| 英文同义词 | NucPE1;Nuclear Peroxy Emerald 1, >98%;NUCPE1?, >98%;Nuclear Peroxy Emerald 1;3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9'-xanthene]-1-one;Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- |
| CAS号 | 1404091-23-1 |
| 分子式 | C29H30BNO5 |
| 分子量 | 483.36 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1404091-23-1.mol |
| 结构式 |  |
1404091-23-1 性质
| 沸点 | 643.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.40±0.20(Predicted) |
NucPE1 features two major visible region absorptions (λ abs =468 nm, ε=27,300 M -1 cm -1 ; λ abs =490 nm, ε=26,000 M -1 cm -1 ) and a weak emission (λ em =530 nm, Φ=0.117). Reaction of NucPE1 with H 2 O 2 triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M -1 cm -1 ) with enhanced emission (λ em =530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like C. clegans , where it can respond to subcellular changes in H 2 O 2 fluxes.
NucPE1 maintains the ability to selectively target nuclei in vivo . NucPE1 imaging reveals a reduction in nuclear H 2 O 2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-101859 | 1404091-23-1 NucPE1 | 1404091-23-1 | 1mg | 1500元 |
| 2024/04/30 | HY-101859 | 1404091-23-1 NucPE1 | 1404091-23-1 | 5mg | 4500元 |