COMPOUND 3K
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- CAS号:
- 94164-88-2
- 英文名:
- PKM2 inhibitor
- 英文别名:
- PKM2-IN-1;compound 3k;PKM2 inhibitor;PKM2 inhibitor 1;PKM2-IN-1;COMPOUND 3K;PKM2 inhibitor(compound 3k);Pyruvate Kinase,inhibit,PKM2 IN 1,Inhibitor,PKM2IN1,PKM-2-IN-1;piperidine-1-carbodithioic acid 3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylmethyl ester;1-Piperidinecarbodithioic acid, (1,4-dihydro-3-methyl-1,4-dioxo-2-naphthalenyl)methyl ester
- 中文名:
- COMPOUND 3K
- 中文别名:
- PKM2抑制剂(化合物3K);化合物PKM2 INHIBITOR;PKM2抑制剂(PKM2-IN-1);(3-甲基-1,4-二氧代-1,4-二氢萘-2-基)甲基 哌啶-1-二硫代甲酸酯
- CBNumber:
- CB23350586
- 分子式:
- C18H19NO2S2
- 分子量:
- 345.48
- MOL File:
- 94164-88-2.mol
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COMPOUND 3K化学性质
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沸点:
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496.5±55.0 °C(Predicted)
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密度:
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1.302±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMF: 1 mg/ml; DMSO: insol; Ethanol: insol; PBS (pH 7.2): insol
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形态:
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A solid
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酸度系数(pKa):
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0.81±0.20(Predicted)
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COMPOUND 3K性质、用途与生产工艺
PKM2-IN-1 是一种丙酮酸激酶 M2 (PKM2) 抑制剂，其 IC50 值为 2.95 μM。
PKM2-IN-1 is a pyruvate kinase M2 (PKM2) inhibitor with an IC
50
of 2.95±0.53 μM. Results show that most of the tested compounds exhibit some degree of PKM2 inhibition and some compounds, such as PKM2-IN-1 (compound 3k) and 6d, display more potent activity than the positive control shikonin. The representative compounds PKM2-IN-1, 6d display dose-dependent inhibition of PKM2 with less inhibition of PKM1 and PKL like shikonin. Among all tested compounds, the most potent compounds are 3a, PKM2-IN-1 and 3r, which exhibit IC
50
values against HCT116 and Hela cells ranging from 0.39 to 0.41 μM, 0.18 to 0.29 μM and 0.18 to 0.38 μM, respectively.
COMPOUND 3K
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-103617 | PKM2-IN-1 | | 1 mg | 320元 |
| 2024/01/25 | HY-103617 | COMPOUND 3K
PKM2-IN-1 | 94164-88-2 | 5mg | 800元 |
94164-88-2, COMPOUND 3K 相关搜索:
- 药靶配体
- 细胞生物学试剂
- (3-甲基-1,4-二氧代-1,4-二氢萘-2-基)甲基 哌啶-1-二硫代甲酸酯
- 化合物PKM2 INHIBITOR
- PKM2抑制剂(PKM2-IN-1)
- PKM2抑制剂(化合物3K)
- 94164-88-2
- Pyruvate Kinase,inhibit,PKM2 IN 1,Inhibitor,PKM2IN1,PKM-2-IN-1
- 1-Piperidinecarbodithioic acid, (1,4-dihydro-3-methyl-1,4-dioxo-2-naphthalenyl)methyl ester
- PKM2 inhibitor 1
- piperidine-1-carbodithioic acid 3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-ylmethyl ester
- PKM2-IN-1;COMPOUND 3K
- PKM2 inhibitor(compound 3k)
- compound 3k
- PKM2-IN-1
- PKM2 inhibitor