133406-29-8
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- CAS号:
- 133406-29-8
- 英文名:
- ST034307
- 英文别名:
- ST034307;ST034307 >=98% (HPLC);ST034307;ST-034307;ST 034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase
- 中文名:
- 133406-29-8
- 中文别名:
- 化合物ST034307;6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮;ST 034307,腺苷酸环化酶1(AC1)抑制剂
- CBNumber:
- CB23356179
- 分子式:
- C10H4Cl4O2
- 分子量:
- 297.95
- MOL File:
- 133406-29-8.mol
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133406-29-8化学性质
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沸点:
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329.1±42.0 °C(Predicted)
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密度:
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1.674±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
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形态:
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solid
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颜色:
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Yellow
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稳定性:
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Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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133406-29-8性质、用途与生产工艺
ST034307 是一种有效的，选择性的 adenylyl cyclase 1 抑制剂，IC50 值为 2.3 μM。
ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca
2+
/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1.
ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E
50
) value for analgesia of 0.28 μg in the mouse pain model.
133406-29-8
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101279 | 133406-29-8
ST034307 | 133406-29-8 | 5mg | 770元 |
| 2024/04/30 | HY-101279 | 133406-29-8
ST034307 | 133406-29-8 | 10mM * 1mLin DMSO | 847元 |
133406-29-8, 133406-29-8 相关搜索:
- 合成有机化合物配体
- ST 034307,腺苷酸环化酶1(AC1)抑制剂
- 化合物ST034307
- 6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮
- 133406-29-8
- Adenylate Cyclase,Inhibitor,ST 034307,inhibit,ST034307,ST-034307,Adenylyl cyclase
- ST034307 >=98% (HPLC)
- 4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-
- 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
- ST034307;ST-034307;ST 034307
- 6-chloro-2-(trichloromethyl)-4H-chromen-4-one
- ST034307