PRION PROTEIN (106-126) (HUMAN)
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- CAS号:
- 148439-49-0
- 英文名:
- H-LYS-THR-ASN-MET-LYS-HIS-MET-ALA-GLY-ALA-ALA-ALA-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY-OH
- 英文别名:
- PRP (106-126);PRP106-126, HUMAN;KTNMKHMAGAAAAGAVVGGLG;H-KTNMKHMAGAAAAGAWGGLG-OH;H-KTNMKHMAGAAAAGAVVGGLG-OH;106-126-Prion protein (human);PRION PEPTIDE (106-126), HUMAN;PRION PROTEIN (106-126) (HUMAN);PRION PROTEIN FRAGMENT 106-126 HUMAN;106-126-Prion protein PrP (synthetic)
- 中文名:
- PRION PROTEIN (106-126) (HUMAN)
- 中文别名:
- PRION片段多肽;106-126-朊蛋白
- CBNumber:
- CB2350990
- 分子式:
- C80H138N26O24S2
- 分子量:
- 1912.24
- MOL File:
- 148439-49-0.mol
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PRION PROTEIN (106-126) (HUMAN)化学性质
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沸点:
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2216.1±65.0 °C(Predicted)
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密度:
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1.283±0.06 g/cm3(Predicted)
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储存条件:
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−20°C
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酸度系数(pKa):
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3.33±0.10(Predicted)
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形态:
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solid
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水溶解性:
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Soluble to 1 mg/ml in water
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PRION PROTEIN (106-126) (HUMAN)性质、用途与生产工艺
Prion Protein 106-126 (human) 是 Prion 的多肽片段，它可以诱导神经元凋亡，抗蛋白酶 K 消化，纤维形成，并介导正常细胞病毒蛋白 (PrPc) 转化为致病同工型 (PrPSc)。Prion Protein 106-126 (human) 通常用作研究朊病毒蛋白疾病中神经变性的模型。
PrP (106-126) (100 μM) induces mTOR phosphorylation over time in N2a cells. PrP (106-126)-treated cells show significantly increased ROS production in comparison with that of PBS-treated control cells. Knockdown of PRAS40 enhances PrP (106-126)-induced apoptosis. PRAS40 alleviates PrP (106-126)-induced neuronal apoptosis via mTOR-AKT activation. PrP (106-126) interacts selectively with porcine brain endothelial cells (PBEC) via their luminal side, and causes cumulative cell death, as shown by lactate dehydrogenase release, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, Caspase 3 induction and direct cell counting. In addition, PrP (106-126), but not its corresponding scrambled peptide, produces a 50% reduction of the trans-endothelial electrical resistance, while the PBEC maintained confluency.
PRION PROTEIN (106-126) (HUMAN)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN)
PrP 106-126 | 148439-49-0 | 500μg | 900元 |
| 2024/01/25 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN)
PrP 106-126 | 148439-49-0 | 1mg | 1600元 |
PRION PROTEIN (106-126) (HUMAN)
生产厂家
148439-49-0, PRION PROTEIN (106-126) (HUMAN) 相关搜索:
- Peptide
- 目录肽
- 目录多肽
- 标准品
- 其他生化试剂
- 生化试剂
- 多肽
- Neurodegenerative Disease Peptides
- Prion Protein Fragments
- Peptides
- BioChemical
- Amino Acids and Peptides
- Biochemicals and Reagents
- C80H138N26O24S2
- PRION片段多肽
- 106-126-朊蛋白
- 148439-49-0
- Prion Protein Fragment 106-126 Human >=90% (HPLC), solid
- Prion protein fragment 106-126 human, ≥90% (HPLC)
- Glycine,L-lysyl-L-threonyl-L-asparaginyl-L-methionyl-L-lysyl-L-histidyl-L-methionyl-L-alanylglycyl-L-alanyl-L-alanyl-L-alanyl-L-alanylglycyl-L-alanyl-L-valyl-L-valylglycylglycyl-L-leucyl-
- REF DUPL: H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH
- 106-126-Prion protein PrP (synthetic)
- 106-126-Prion protein (human)
- 06-126-Prion protein (synthetic fragment PrP106-126)
- PRP106-126, HUMAN
- PRP (106-126)
- PRION PROTEIN (106-126) (HUMAN)
- PRION PEPTIDE (106-126), HUMAN
- PRION PROTEIN FRAGMENT 106-126 HUMAN
- LYS-THR-ASN-MET-LYS-HIS-MET-ALA-GLY-ALA-ALA-ALA-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY
- KTNMKHMAGAAAAGAVVGGLG
- H-LYS-THR-ASN-MET-LYS-HIS-MET-ALA-GLY-ALA-ALA-ALA-ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY-OH
- H-KTNMKHMAGAAAAGAWGGLG-OH
- H-KTNMKHMAGAAAAGAVVGGLG-OH