呋喃茶碱
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- CAS号:
- 80288-49-9
- 英文名:
- 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
- 英文别名:
- Furafilina;FURAFYLLINE;Furafyllinum;Furatheophylline;Furafylline, PDE inhibitor;Furafylline, 10 mM in DMSO;FURAFYLLINE INHIBITOR OF CYTOCHRO;Cytochrome P450,inhibit,Inhibitor,CYPs,Furafylline;3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione;3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
- 中文名:
- 呋喃茶碱
- 中文别名:
- 呋拉茶碱;呋喃菲林;呋喃茶碱;呋喃茶碱标准品;呋拉茶碱,10 MM DMSO 溶液;FURAFYLLINE,PDE抑制剂;3-(呋喃-2-基甲基)-1,8-二甲基-1H-嘌呤-2,6(3H,7H)-二酮
- CBNumber:
- CB2360403
- 分子式:
- C12H12N4O3
- 分子量:
- 260.25
- MOL File:
- 80288-49-9.mol
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呋喃茶碱化学性质
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熔点:
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>162°C (dec.)
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沸点:
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543.6±60.0 °C(Predicted)
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密度:
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1.443±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C(protect from light)
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溶解度:
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ethanol: 0.33 mg/mL
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形态:
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solid
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酸度系数(pKa):
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8.62±0.70(Predicted)
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颜色:
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white
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InChI:
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InChI=1S/C12H12N4O3/c1-7-13-9-10(14-7)16(6-8-4-3-5-19-8)12(18)15(2)11(9)17/h3-5H,6H2,1-2H3,(H,13,14)
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InChIKey:
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KGQZGCIVHYLPBH-UHFFFAOYSA-N
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SMILES:
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N1C2=C(N(CC3=CC=CO3)C(=O)N(C)C2=O)NC=1C
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呋喃茶碱性质、用途与生产工艺
Furafylline 是一种有效且有选择性的人细胞色素 P450IA2 抑制剂，其 IC50 值为 0.07 μM。
IC50: 0.07 μM (human cytochrome P450IA2)
Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC
50
of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.
呋喃茶碱
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2025/05/22 | HY-107204 | 呋喃茶碱
Furafylline | 80288-49-9 | 5mg | 2180元 |
| 2025/05/22 | HY-107204 | 呋喃茶碱
Furafylline | 80288-49-9 | 10 mM * 1 mLin DMSO | 2398元 |
呋喃茶碱
生产厂家
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呋喃茶碱国内生产厂家
80288-49-9, 呋喃茶碱 相关搜索:
- 杂质对照品
- 抑制剂
- 药靶配体
- 试剂
- Phosphodiesterase Inhibitors
- Cyclic Nucleotide Metabolism
- G Proteins and Cyclic Nucleotides
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- C12H12N4O3
- 呋拉茶碱,10 MM DMSO 溶液
- FURAFYLLINE,PDE抑制剂
- 呋喃茶碱标准品
- 3-(呋喃-2-基甲基)-1,8-二甲基-1H-嘌呤-2,6(3H,7H)-二酮
- 呋拉茶碱
- 呋喃菲林
- 呋喃茶碱
- 80288-49-9
- 3-(furan-2-ylmethyl)-1,8-dimethyl-7H-purine-2,6-dione - [AC80897]
- Furafylline, 10 mM in DMSO
- Furafylline, PDE inhibitor
- Furafyllinum
- Furafilina
- Furatheophylline
- Cytochrome P450,inhibit,Inhibitor,CYPs,Furafylline
- 3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione
- 1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl-
- FURAFYLLINE INHIBITOR OF CYTOCHRO
- Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione
- 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE
- FURAFYLLINE