奥克太尔
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- CAS号:
- 36531-26-7
- 英文名:
- OXANTEL
- 英文别名:
- OXANTEL;Telopar;CP-14445-16;OXANTEL USP/EP/BP;3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol;(E)-3-(2-(1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinyl)vinyl)phenol;3-[(E)-2-(1,4,5,6-Tetrahydro-1-methylpyrimidin-2-yl)vinyl]phenol;Phenol, 3-[(1E)-2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenyl]-
- 中文名:
- 奥克太尔
- 中文别名:
- 间酚嘧啶;奥克太尔;奥克生太;化合物 T0323L
- CBNumber:
- CB2376185
- 分子式:
- C13H16N2O
- 分子量:
- 216.28
- MOL File:
- 36531-26-7.mol
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奥克太尔化学性质
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沸点:
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383.1±52.0 °C(Predicted)
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密度:
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1.09±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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9.42±0.10(Predicted)
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奥克太尔性质、用途与生产工艺
Oxantel (CP-14445) 是 Pyrantel (HY-12641) 的衍生物，是 N-亚型的 AChR 激动剂。Oxantel 是一种驱虫剂，具有优良驱虫活性。
Oxantel ( 0.015-600 µg/mL; 24-72 hours) reduces the viability of
T. muris
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Cell Viability Assay
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Cell Line:
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T. muris
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Concentration:
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0.015 µg/mL, 0.3 µg/mL, 0.6 µg/mL, 4.66 µg/mL, 9.375 µg/mL, 150 µg/mL, 600 µg/mL
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Incubation Time:
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24 hours, 48 hours, 72 hours
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Result:
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Resulted in strongly reduced viabilities; resulted in strongly reduced viabilities within 24 hours but did not kill the worms.
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Oxantel (1-10 mg/kg; i.p.) displays a high activity against
T. muris
in vivo, with an EC
50
of 4.71 mg/kg.
Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for
T. muris
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Animal Model:
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4 week-old female C57BL/10 mice and 3 week-old male
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Dosage:
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1 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:
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Intraperitoneal injection
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Result:
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Inhibited
T. muris
in vivo.
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奥克太尔
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36531-26-7, 奥克太尔 相关搜索:
- 化合物 T0323L
- 间酚嘧啶
- 奥克太尔
- 奥克生太
- 36531-26-7
- OXANTEL USP/EP/BP
- Phenol, 3-[(1E)-2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenyl]-
- 3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol
- (E)-3-(2-(1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinyl)vinyl)phenol
- Telopar
- CP-14445-16
- 3-[(E)-2-(1,4,5,6-Tetrahydro-1-methylpyrimidin-2-yl)vinyl]phenol
- OXANTEL