卡西霉素
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- CAS号:
- 59450-89-4
- 英文名:
- CALCIMYCIN HEMICALCIUM SALT
- 英文别名:
- A23187 HEMICALCIUM SALT;CALCIMYCIN A23187 HEMICALCIUM SALT;Antibiotic A-23187 hemicalcium salt;calcium ionophore A23187 hemicalcium;CALCIUM IONOPHORE A23187 HEMICALCIUM SALT;Calcium Ionophore A23187 hemicalcium salt powder;CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA;A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt;5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate;5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
- 中文名:
- 卡西霉素
- 中文别名:
- 卡西霉素;化合物 T10662;A23187 半钙盐;钙离子载体 A23187 半钙盐
- CBNumber:
- CB2719962
- 分子式:
- C58H72CaN6O12
- 分子量:
- 1085.32
- MOL File:
- 59450-89-4.mol
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卡西霉素化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble
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形态:
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powder
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颜色:
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yellow
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BRN:
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6765084
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卡西霉素性质、用途与生产工艺
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) 是一种抗生素和独特的二价阳离子离子载体 (divalent cation ionophore),如钙离子和镁离子。Calcimycin hemicalcium salt 通过增加细胞内钙浓度诱导 Ca2+ 依赖性细胞死亡。Calcimycin hemicalcium salt 抑制革兰氏阳性细菌和一些真菌的生长,还抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化 (OXPHOS),诱导细胞凋亡 (apoptosis)。
Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner.
Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage.
Animal Model:
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Mice (ICR, 25-30 g)
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Dosage:
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2.5 or 7.5 nM
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Administration:
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Intrapleurally
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Result:
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Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
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用途
高选择性钙离子载体增强对NMDA非使君子氨酸的响应。在细胞培养中,通过钙调素依赖结构型一氧化氮合酶刺激一氧化氮的生成。
卡西霉素
上下游产品信息
上游原料
下游产品
59450-89-4, 卡西霉素 相关搜索:
- Antibiotics A-F
- Antibiotics A to Z
- Antibiotics
- BioChemical
- C58H72CaN6O12
- C29H36Ca05N3O6
- 化合物 T10662
- 卡西霉素
- 钙离子载体 A23187 半钙盐
- A23187 半钙盐
- 59450-89-4
- Calcium Ionophore A23187 hemicalcium salt powder
- Antibiotic A-23187 hemicalcium salt
- 5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
- 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylate
- A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt
- CALCIUM IONOPHORE A23187 HEMICALCIUM SALT BIOCHEMIKA
- calcium ionophore A23187 hemicalcium
- CALCIMYCIN A23187 HEMICALCIUM SALT
- CALCIUM IONOPHORE A23187 HEMICALCIUM SALT
- A23187 HEMICALCIUM SALT