NS 5806
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- CAS号:
- 426834-69-7
- 英文名:
- NS 5806
- 英文别名:
- NS 5806;N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]--N'-[2,4-DIBROMO-6-(2H-TETRAZOL-5-YL)PHENYL]UREA;N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-;Potassium Channel,KV4.3,Inhibitor,KcsA,dacay,NS 5806,peak,KChIP2,Ito,KV4.2,current,inhibit,amplitudes,NS5806
- 中文名:
- NS 5806
- 中文别名:
- 化合物NS5806;N-[3,5-双(三氟甲基)苯基]-N'-[2,4-二溴-6-(2H-四唑-5-基)苯基]脲
- CBNumber:
- CB32535686
- 分子式:
- C16H8Br2F6N6O
- 分子量:
- 574.07
- MOL File:
- 426834-69-7.mol
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NS 5806化学性质
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密度:
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1.962±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >30mg/mL
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酸度系数(pKa):
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3.54±0.10(Predicted)
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形态:
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powder
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颜色:
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white to faint yellow
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NS 5806性质、用途与生产工艺
NS5806 是一种有效的钾电流激活剂，可增加 KV4.3/KChIP2 峰值电流幅度，EC50 为 5.3 μM。NS5806 会在包含 KChIP2 的通道复合体中降低 KV4.3 和 KV4.2 电流衰减。
NS5806 (10 µM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC
50
value of 25.4 µM in CHO-K1 cells.
NS5806 activates canine transient outward potassium current (Ito) with an IC
50
of 40.7 nM and an EC
50
of 1.6 nM for inhibition and stimulation on rabbit, respectively.
NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito.
NS 5806
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108588 | NS5806 | | 1 mg | 571元 |
| 2024/04/30 | HY-108588 | NS 5806
NS5806 | 426834-69-7 | 5mg | 1500元 |
426834-69-7, NS 5806 相关搜索:
- C16H8Br2F6N6O
- 化合物NS5806
- N-[3,5-双(三氟甲基)苯基]-N'-[2,4-二溴-6-(2H-四唑-5-基)苯基]脲
- 426834-69-7
- Potassium Channel,KV4.3,Inhibitor,KcsA,dacay,NS 5806,peak,KChIP2,Ito,KV4.2,current,inhibit,amplitudes,NS5806
- Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-
- N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]--N'-[2,4-DIBROMO-6-(2H-TETRAZOL-5-YL)PHENYL]UREA
- N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea
- NS 5806