NS 5806
| 中文名称 | NS 5806 |
|---|---|
| 中文同义词 | N-[3,5-双(三氟甲基)苯基]-N'-[2,4-二溴-6-(2H-四唑-5-基)苯基]脲;化合物NS5806;化合物NS5806,10 MM DMSO 溶液;1-(3,5-双(三氟甲基)苯基)-3-(2,4-二溴-6-(1H-四唑-5-基)苯基)脲 |
| 英文名称 | NS 5806 |
| 英文同义词 | NS 5806;N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea;N-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]--N'-[2,4-DIBROMO-6-(2H-TETRAZOL-5-YL)PHENYL]UREA;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]-;Potassium Channel,KV4.3,Inhibitor,KcsA,dacay,NS 5806,peak,KChIP2,Ito,KV4.2,current,inhibit,amplitudes,NS5806;1-[3,5-bis(trifluoromethyl)phenyl]-3-[2,4-dibromo-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea;NS5806, 10 mM in DMSO;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl)urea |
| CAS号 | 426834-69-7 |
| 分子式 | C16H8Br2F6N6O |
| 分子量 | 574.07 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 426834-69-7.mol |
| 结构式 |  |
NS 5806 性质
| 密度 | 1.962±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>30mg/mL |
| 酸度系数(pKa) | 3.54±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至淡黄色 |
| InChI | InChI=1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30) |
| InChIKey | UZWJWROOLOOCPQ-UHFFFAOYSA-N |
| SMILES | N(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C(NC1=C(C2=NNN=N2)C=C(Br)C=C1Br)=O |
NS5806 是一种有效的钾电流激活剂，可增加 KV4.3/KChIP2 峰值电流幅度，EC50 为 5.3 μM。NS5806 会在包含 KChIP2 的通道复合体中降低 KV4.3 和 KV4.2 电流衰减。
IC50: 5.3 nM (K V 4.3)
NS5806 (10 µM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC
50
value of 25.4 µM in CHO-K1 cells.
NS5806 activates canine transient outward potassium current (Ito) with an IC
50
of 40.7 nM and an EC
50
of 1.6 nM for inhibition and stimulation on rabbit, respectively.
NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-108588 | NS5806 | 426834-69-7 | 1 mg | 571元 |
| 2026/09/15 | HY-108588 | NS 5806 NS5806 | 426834-69-7 | 5mg | 1500元 |