PF 4800567
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- CAS号:
- 1188296-52-7
- 英文名:
- PF 4800567 hydrochloride
- 英文别名:
- PF 4800567;PF 4800567;PF-4800567;PF 4800567 hydrochloride;Casein Kinase,PF4800567,inhibit,PF-4800567,PF 4800567,Inhibitor;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine;3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-;3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride
- 中文名:
- PF 4800567
- 中文别名:
- PF-4800567游离态;化合物PF-4800567;3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑啉[3,4-D]嘧啶-4-胺;3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺
- CBNumber:
- CB32561076
- 分子式:
- C17H18ClN5O2
- 分子量:
- 359.81
- MOL File:
- 1188296-52-7.mol
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PF 4800567化学性质
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沸点:
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592.9±50.0 °C(Predicted)
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密度:
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1.52±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
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溶解度:
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DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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4.01±0.30(Predicted)
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颜色:
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Light yellow to yellow
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PF 4800567性质、用途与生产工艺
PF 4800567是casein kinase 1 epsilon (IC50=32 nM) 的新型有效抑制剂,其选择性是casein kinase 1 delta(IC50=711 nM)的20倍以上。
Target | Value |
casein kinase 1 epsilon
(Cell-free assay)
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32 nM
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casein kinase 1 delta
()
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711 nM
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PF-4800567 is a potent and selective inhibitor of casein kinase 1ϵ (CK1ϵ), with an IC
50
of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC
50
, 711 nM). PF-4800567 shows inhibitory activity against CK1ϵ and CK1δ in whole cells, with IC
50
s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1ϵ-mediated PER3 nuclear localization mediated by CK1ϵ and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM.
PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice.
用途
PF 4800567 is a selective casein kinase inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays
minimal effect on the circadian clock.
PF 4800567
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-12470 | PF-4800567 | | 1 mg | 335元 |
2024/08/19 | HY-12470 | 3-((3-氯苯氧基)甲基)-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺 PF-4800567 | 1188296-52-7 | 5mg | 800元 |
1188296-52-7, PF 4800567 相关搜索:
- 合成有机化合物配体
- 3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑啉[3,4-D]嘧啶-4-胺
- PF-4800567游离态
- 化合物PF-4800567
- 3-[(3-氯苯氧基)甲基]-1-(四氢-2H-吡喃-4-基)-1H-吡唑并[3,4-D]嘧啶-4-胺
- 1188296-52-7
- Casein Kinase,PF4800567,inhibit,PF-4800567,PF 4800567,Inhibitor
- 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-
- PF 4800567;PF-4800567
- 3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine
- PF 4800567 hydrochloride
- 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- PF 4800567
- 3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride