AUDA
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- CAS号:
- 479413-70-2
- 英文名:
- AUDA
- 英文别名:
- AUDA;12-(3-adamantan-1-yl-ureido)dodecanoic acid;12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid;Dodecanoic acid, 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-;Inhibitor,anti-inflammatory,epoxide,inhibit,hydrolase,sEH,activity,AUDA,soluble,Epoxide Hydrolase,VSMC
- 中文名:
- AUDA
- 中文别名:
- 化合物AUDA;12-(3-(金刚烷-1-基)脲基)十二酸
- CBNumber:
- CB32590311
- 分子式:
- C23H40N2O3
- 分子量:
- 392.58
- MOL File:
- 479413-70-2.mol
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AUDA化学性质
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熔点:
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114 °C(Solv: hexane (110-54-3))
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沸点:
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592.7±19.0 °C(Predicted)
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密度:
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1.09±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,Store in freezer, under -20°C
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溶解度:
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DMSO: ≥10mg/mL at warmed to 60°C
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形态:
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powder
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酸度系数(pKa):
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4.78±0.10(Predicted)
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颜色:
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white to beige
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AUDA性质、用途与生产工艺
AUDA (compound 43) 是一种有效的 soluble epoxide hydrolase (sEH) 的抑制剂，对小鼠sEH和人sEH的IC50值分别为18 nM和69 nM。AUDA具有抗炎活性，可降低MMP-9、IL-1β、TNF-α 和 TGF-β。AUDA还可下调 Smad3 和 p38 信号通路。
| Target | Value |
MMP-9
()
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IL-1β
()
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TNF-α
()
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TGF-β
()
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Smad3
()
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AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF.
AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression.
AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner.
AUDA significantly increases the adhesion ability of HCAECs.
Cell Proliferation Assay
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Cell Line:
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Vascular smooth muscle cell (VSMC)
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Concentration:
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0.3, 1, 3, 10 μg/mL
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Incubation Time:
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48 hours
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Result:
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Dose-dependently suppressed the proliferation of rat VSMCs exposed to PDGF.
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Western Blot Analysis
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Cell Line:
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VSMC
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Concentration:
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1, 3, 10, 30 μg/mL
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Incubation Time:
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30 min
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Result:
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Dose-dependently upregulated COX-2 expression.
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AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.
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Animal Model:
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Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g)
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Dosage:
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10 mg/kg
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Administration:
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i.p.; 14 days
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Result:
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Reduced TNF-α, MMP-9 and IL-1β expression levels.
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AUDA
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108570 | AUDA | | 5 mg | 343元 |
| 2024/04/30 | HY-108570 | AUDA
AUDA | 479413-70-2 | 10mM * 1mLin DMSO | 610元 |
479413-70-2, AUDA 相关搜索:
- 药靶配体
- 抗体-二抗
- C23H40N2O3
- 化合物AUDA
- 12-(3-(金刚烷-1-基)脲基)十二酸
- 479413-70-2
- Inhibitor,anti-inflammatory,epoxide,inhibit,hydrolase,sEH,activity,AUDA,soluble,Epoxide Hydrolase,VSMC
- Dodecanoic acid, 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-
- 12-(3-adamantan-1-yl-ureido)dodecanoic acid
- 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid
- AUDA