AUDA
中文名称 | AUDA |
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中文同义词 | 12-(3-(金刚烷-1-基)脲基)十二酸;化合物AUDA |
英文名称 | AUDA |
英文同义词 | AUDA;12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid;12-(3-adamantan-1-yl-ureido)dodecanoic acid;Dodecanoic acid, 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-;Inhibitor,anti-inflammatory,epoxide,inhibit,hydrolase,sEH,activity,AUDA,soluble,Epoxide Hydrolase,VSMC |
CAS号 | 479413-70-2 |
分子式 | C23H40N2O3 |
分子量 | 392.58 |
EINECS号 | |
相关类别 | 抗体-二抗 |
Mol文件 | 479413-70-2.mol |
结构式 |
AUDA 性质
熔点 | 114 °C(Solv: hexane (110-54-3)) |
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沸点 | 592.7±19.0 °C(Predicted) |
密度 | 1.09±0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,Store in freezer, under -20°C |
溶解度 | DMSO:加热至60℃时≥10mg/mL |
形态 | 粉末 |
酸度系数(pKa) | 4.78±0.10(Predicted) |
颜色 | 白色至米色 |
Target | Value |
MMP-9
() | |
IL-1β
() | |
TNF-α
() | |
TGF-β
() | |
Smad3
() |
AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF.
AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression.
AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner.
AUDA significantly increases the adhesion ability of HCAECs.
Cell Proliferation Assay
Cell Line: | Vascular smooth muscle cell (VSMC) |
Concentration: | 0.3, 1, 3, 10 μg/mL |
Incubation Time: | 48 hours |
Result: | Dose-dependently suppressed the proliferation of rat VSMCs exposed to PDGF. |
Western Blot Analysis
Cell Line: | VSMC |
Concentration: | 1, 3, 10, 30 μg/mL |
Incubation Time: | 30 min |
Result: | Dose-dependently upregulated COX-2 expression. |
AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.
Animal Model: | Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g) |
Dosage: | 10 mg/kg |
Administration: | i.p.; 14 days |
Result: | Reduced TNF-α, MMP-9 and IL-1β expression levels. |
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-108570 | AUDA | 5 mg | 343元 | |
2024/08/19 | HY-108570 | AUDA AUDA | 479413-70-2 | 10mg | 550元 |