189699-82-9
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- CAS号:
- 189699-82-9
- 英文名:
- FR-188582
- 英文别名:
- FR-188582;FR 188582,FR188582;1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-
- 中文名:
- 189699-82-9
- 中文别名:
- 化合物 T15345
- CBNumber:
- CB33339656
- 分子式:
- C16H13ClN2O2S
- 分子量:
- 332.8
- MOL File:
- 189699-82-9.mol
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189699-82-9化学性质
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沸点:
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539.7±50.0 °C(Predicted)
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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-3.80±0.10(Predicted)
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189699-82-9性质、用途与生产工艺
FR-188582 是高选择性的环氧合酶 (COX-2) 抑制剂，IC50 值为 17 nM。
In a recombinant human cyclooxygenase (COX) enzyme activity, FR-188582 (FR188582) inhibits COX-2 with an IC
50
value of 17 nM, and the inhibition of prostaglandin (PG) E2 formation by FR188582 isover 6000 times more selective for COX-2 than COX-1.
Oral administration of FR-188582 (0.01-3.2 mg/kg) reverses paw edema in adjuvant arthritic rats and shows a therapeutic effect in a dose-dependent manner with ED
50
values (95% C.L.) of 0.074 (0.00021-0.53) and 0.063 (0.0039-0.31) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively. The anti-inflammatory effect of FR-188582 (FR188582) is threefold more potent than that of Indomethacin with ED
50
values (95% C.L.) of 0.24 (0.047-1.8) and 0.20 (0.021-0.79) mg/kg for adjuvant-injected paws and adjuvant-uninjected paws, respectively.
189699-82-9
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-U00146 | 189699-82-9
FR-188582 | 189699-82-9 | 1mg | 3000元 |
| 2024/01/25 | HY-U00146 | 189699-82-9
FR-188582 | 189699-82-9 | 5mg | 6000元 |
189699-82-9, 189699-82-9 相关搜索:
- 化合物 T15345
- 189699-82-9
- FR 188582,FR188582
- 1H-Pyrazole, 3-chloro-5-[4-(methylsulfonyl)phenyl]-1-phenyl-
- FR-188582