CYN 154806; CYN154806
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- CAS号:
- 183658-72-2
- 英文名:
- CYN 154806
- 英文别名:
- CYN 154806;CYANAMID 154806;CYN 154806; CYN154806;M.W. 1197.35 C56H68N12O14S2;CYN 154806 TRIFLUOROACETATE SALT;CYANAMID 154806 trifluoroacetate salt;AC-(4-NITRO)PHE-D-CYS-TYR-D-TRP-LYS-THR-CYS-D-TYR-NH2;Ac-4-NO2-Phe-c(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH2;D-Tyrosinamide, N-acetyl-4-nitro-L-phenylalanyl-D-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide
- 中文名:
- CYN 154806; CYN154806
- 中文别名:
- CBNumber:
- CB3428029
- 分子式:
- C56H68N12O14S2
- 分子量:
- 1197.34
- MOL File:
- 183658-72-2.mol
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CYN 154806; CYN154806化学性质
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沸点:
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1656.2±65.0 °C(Predicted)
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密度:
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1.47±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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酸度系数(pKa):
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9.87±0.15(Predicted)
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形态:
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powder
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颜色:
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white to off-white
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水溶解性:
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Soluble to 1 mg/ml in water
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CYN 154806; CYN154806性质、用途与生产工艺
CYN 154806 是一种环状八肽，是一种强效的，选择性生长抑素 sst2 受体的拮抗剂，其对人重组 sst2、sst1、sst3、sst4 和sst5 受体的 pIC50 值分别为 8.58、5.41、6.07、5.76 和 6.48。
CYN 154806 inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively).
CYN 154806 (0.1 mg/kg; i.p.; 20 min before the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice.
CYN 154806; CYN154806
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-P1202 | CYN 154806 | | 1 mg | 1800元 |
| 2024/01/25 | HY-P1202 | CYN 154806 | | 5 mg | 3800元 |
CYN 154806; CYN154806
生产厂家
183658-72-2, CYN 154806; CYN154806 相关搜索:
- Somatostatin receptor
- 环肽
- C56H68N12O14S2
- 183658-72-2
- Ac-4-NO2-Phe-c(D-Cys-Tyr-D-Trp-Lys-Thr-Cys)-D-Tyr-NH2
- D-Tyrosinamide, N-acetyl-4-nitro-L-phenylalanyl-D-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide
- CYN 154806; CYN154806
- M.W. 1197.35 C56H68N12O14S2
- CYANAMID 154806 trifluoroacetate salt
- CYN 154806 TRIFLUOROACETATE SALT
- AC-(4-NITRO)PHE-D-CYS-TYR-D-TRP-LYS-THR-CYS-D-TYR-NH2
- CYANAMID 154806
- CYN 154806