盐酸帕多芦诺
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- CAS号:
- 269718-83-4
- 英文名:
- 2(3H)-BENZOXAZOLONE, 7-(4-METHYL-1-PIPERAZINYL)-, MONOHYDROCHLORIDE
- 英文别名:
- Pardoprunox HCI;pardoprunox.HCl;pardoprunox.HCl.H2O;SLV-308 hydrochloride;DU-126891 hydrochloride;Pardoprunox.HCl(SLV-308);Pardoprunox (hydrochloride);Eicosapentaenoic Acid Impurity 56;Pardoprunox (SLV-308) hydrochloride;SLV-308 HYDROCHLORIDE; DU-126891 HYDROCHLORIDE;SLV308;SLV 308
- 中文名:
- 盐酸帕多芦诺
- 中文别名:
- 盐酸帕多芦诺;帕多芦诺盐酸盐;盐酸帕多普诺(SLV-308);7-(4-甲基哌嗪-1-基)苯并[D]恶唑-2(3H)-酮盐酸盐
- CBNumber:
- CB41009763
- 分子式:
- C12H16ClN3O2
- 分子量:
- 269.72734
- MOL File:
- 269718-83-4.mol
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盐酸帕多芦诺化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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DMSO:5.0(Max Conc. mg/mL);18.5(Max Conc. mM)
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形态:
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A crystalline solid
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盐酸帕多芦诺性质、用途与生产工艺
Pardoprunox hydrochloride (DU-126891, SME-308)是一种有效的部分 dopamine D2 receptor 的激动剂，对应的pEC50值为8.0，也是诱导 [35S]GTPγS binding 的部分激动剂，对应的pEC50值为9.2，和 serotonin 5-HT1A receptor 的激动剂，pEC50值为6.3。
| Target | Value |
[
(Cell-free assay)
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9.2(pEC50)
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D2 receptor
(Cell-free assay)
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8.0(pEC50)
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5-HT1A receptor
(Cell-free assay)
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6.3(pEC50)
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Pardoprunox (SLV-308) hydrochloride acts as a potent but partial D2 receptor agonist (pEC
50
= 8.0 and pA
2
=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox hydrochloride acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC
50
=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA
2
=9.0). Pardoprunox hydrochloride acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC
50
=6.3).
盐酸帕多芦诺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14958A | 盐酸帕多芦诺
Pardoprunox hydrochloride | 269718-83-4 | 2mg | 2333元 |
| 2024/01/25 | HY-14958A | 盐酸帕多芦诺
Pardoprunox hydrochloride | 269718-83-4 | 10 mM * 1 mLin DMSO | 3461元 |
269718-83-4, 盐酸帕多芦诺 相关搜索:
- 药靶配体
- 医药
- 盐酸帕多普诺(SLV-308)
- 7-(4-甲基哌嗪-1-基)苯并[D]恶唑-2(3H)-酮盐酸盐
- 盐酸帕多芦诺
- 帕多芦诺盐酸盐
- 269718-83-4
- Pardoprunox (SLV-308) hydrochloride
- 7-(4-Methylpiperazin-1-yl)benzo[d]oxazol-2(3H)-one hydrochloride
- Eicosapentaenoic Acid Impurity 56
- Pardoprunox,Serotonin Receptor,DU 126891,Beta Receptor,5-HT Receptor,DU-126891,SLV 308,Inhibitor,inhibit,SLV308,Pardoprunox hydrochloride,SLV-308,Dopamine Receptor,5-hydroxytryptamine Receptor,Adrenergic Receptor,DU126891
- Pardoprunox HCI
- 2(3H)-Benzoxazolone,7-(4-methyl-1-piperazinyl)-, hydrochloride (1:1)
- pardoprunox.HCl.H2O
- SLV-308 HYDROCHLORIDE; DU-126891 HYDROCHLORIDE;SLV308;SLV 308
- DU-126891 hydrochloride
- 2(3H)-BENZOXAZOLONE, 7-(4-METHYL-1-PIPERAZINYL)-, MONOHYDROCHLORIDE
- SLV-308 hydrochloride
- Pardoprunox.HCl(SLV-308)
- pardoprunox.HCl
- Pardoprunox (hydrochloride)