利喷西平
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- CAS号:
- 96449-05-7
- 英文名称:
- Rispenzepine
- 英文同义词:
- Rispenzepine;Unii-W99llm73R7;Rispenzepine [inn];5H-Pyrido[2,3-b][1,5]benzodiazepin-5-one, 6,11-dihydro-11-[(1-methyl-3-piperidinyl)carbonyl]-;11-[(1-methyl-piperidine-3-yl)-carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]-benzodiazepine-5-one
- 中文名称:
- 利喷西平
- 中文同义词:
- 利喷西平;化合物 T16758
- CBNumber:
- CB41402427
- 分子式:
- C19H20N4O2
- 分子量:
- 336.39
- MOL File:
- 96449-05-7.mol
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利喷西平性质、用途与生产工艺
Rispenzepine 是一种选择性毒蕈碱受体 (M1 和 M3 受体亚型) 拮抗剂。
The presence of muscarinic autoreceptors in human and guinea pig trachea is investigated by comparing the effects of the muscarinic receptor antagonists Pirenzepine (M
1
), Methoctramine (M
2
), 4-DAMP (M
3
), and Rispenzepine (M
1
/M
3
) on cholinergic neural contractile responses evoked by electrical field stimulation (EFS) and [
3
H]ACh release. The M
1
, M
1
/M
3
, or M
3
antagonists inhibit the EFS-evoked cholinergic contractile response in a concentration-dependent manner (4-DAMP > Rispenzepine > Pirenzepine), whereas Methoctramine facilitates this response at low concentrations (<3 μM). In ACh release studies, the M
3
antagonist has no significant effect, whereas Pirenzepine, Methoctramine, and Rispenzepine significantly increase ACh release in guinea pig trachea. Rispenzepine almost completely inhibits cholinergic, contractile responses at 0.3 μM (92.7±6.2% inhibition, n=6, p<0.05; pD
2
value of 7.31±0.15) .
利喷西平
上下游产品信息
上游原料
下游产品
96449-05-7, 利喷西平 相关搜索:
- 化合物 T16758
- 利喷西平
- 96449-05-7
- 5H-Pyrido[2,3-b][1,5]benzodiazepin-5-one, 6,11-dihydro-11-[(1-methyl-3-piperidinyl)carbonyl]-
- 11-[(1-methyl-piperidine-3-yl)-carbonyl]-6,11-dihydro-5H-pyrido[2,3-b][1,5]-benzodiazepine-5-one
- Unii-W99llm73R7
- Rispenzepine [inn]
- Rispenzepine