CID24856225
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- CAS号:
- 1073529-41-5
- 英文名:
- CID24856225
- 英文别名:
- ABL127;ML174);CID24856225;ABL127
(AB L127;ABL127 >=98% (HPLC);(3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate;4-OXO-3,3-DIPHENYL-[1,2]DIAZETIDINE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER(WX619174);(3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester;1,2-Diazetidine-1,2-dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-, 1,2-dimethyl ester, (3R)-
- 中文名:
- CID24856225
- 中文别名:
- 化合物 T14084;PME-1抑制剂(ABL127)
- CBNumber:
- CB42750576
- 分子式:
- C17H20N2O5
- 分子量:
- 332.35
- MOL File:
- 1073529-41-5.mol
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CID24856225化学性质
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沸点:
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422.8±48.0 °C(Predicted)
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密度:
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1.330±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥5mg/mL
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酸度系数(pKa):
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-3.45±0.40(Predicted)
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形态:
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film
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颜色:
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colorless
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CID24856225性质、用途与生产工艺
ABL127 是一个有选择且共价的蛋白质甲基酯酶 1 (PME-1) 抑制剂，在 HEK293T 和 MDA-MB-231 细胞中的 IC50 值分别为 6.4 和 4.2 nM。
IC50: 6.4 nM (PME-1 in HEK293T), 4.2 nM (PME-1 in MDA-MB-231)
Three described PME-1 inhibitors are tested in this assay and a thermal shift with 100 μM ABL127 is detected. Using 25 or 50 μM ABL127 also shows a shift in protein melting temperature. It is found that treatment of Ishikawa cells with ABL127 and AMZ-30 significantly decreases cell proliferation similarly to depletion of PME-1 with shRNA. It is also found that treatment of ECC-1 cells with ABL127 or AMZ-30 affects cell invasion in a dose-dependent manner. The treatment of EC cells with ABL127 leads to a significant ~45 % increase in protein phosphatase 2A (PP2A) activity, while treatment with AMZ-30 leads to a modest ~10 % increase in PP2A activity.
No significant decrease in tumor burden can be assessed in these pilot studies. Gel-based profiles indicate that brain PME-1 is inactivated by ABL127, but overlapping serine hydrolase activities preclude a confident assessment of the extent of inactivation.
CID24856225
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-108317 | ABL127 | | 1 mg | 1704元 |
| 2024/01/25 | HY-108317 | CID24856225
ABL127 | 1073529-41-5 | 5mg | 3750元 |
1073529-41-5, CID24856225 相关搜索:
- 制剂-抑制剂
- 细胞生物学试剂
- 化合物 T14084
- PME-1抑制剂(ABL127)
- 1073529-41-5
- ABL127 >=98% (HPLC)
- 1,2-Diazetidine-1,2-dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-, 1,2-dimethyl ester, (3R)-
- ML174)
- ABL127
(AB L127
- 4-OXO-3,3-DIPHENYL-[1,2]DIAZETIDINE-1,2-DICARBOXYLIC ACID DIMETHYL ESTER(WX619174)
- CID24856225
- ABL127
- (3R)-Dimethyl 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylate
- (3R)-1,2-Dicarboxylic acid, 3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine 1,2-dimethyl ester