6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
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- CAS号:
- 160928-38-1
- 英文名:
- 6-N,N-DIETHYL-D-BETA-GAMMA-DIBROMOMETHYLENE ATP
- 英文别名:
- ARL-67156;FPL-67156;FPL 67156 TRISODIUM;ARL 67156 TRISODIUM;ARL 67156 TRISODIUM SALT;ARL 67156 trisodium salt hydrate;6-N,N-Diethyl-D-b,g-dibromomethyleneATP;6-N,N-Diethyl-D-B,G-Dibromomethyleneatp Tri;6-N,N-DIETHYL-D-BETA-GAMMA-DIBROMOMETHYLENE ATP;6-N,N-Diethyl-D-β,γ-dibromomethyleneATPtrisodiumsalt
- 中文名:
- 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
- 中文别名:
- 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
- CBNumber:
- CB4321730
- 分子式:
- C15H24Br2N5O12P3
- 分子量:
- 719.11
- MOL File:
- 160928-38-1.mol
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6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物化学性质
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沸点:
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879.6±75.0 °C(Predicted)
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密度:
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2.32±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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H2O: 10 mg/mL
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形态:
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solid
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酸度系数(pKa):
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0.82±0.50(Predicted)
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颜色:
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off-white
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6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物性质、用途与生产工艺
ARL67156 trisodium salt hydrate 是一种 ecto-ATPase 抑制剂。ARL67156 trisodium salt hydrate 是弱的竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，Ki 分别为 11，18 和 12 μM。ARL67156 trisodium salt hydrate 可预防体内主动脉瓣钙化。
Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)
ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.
Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg).
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Animal Model:
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C57BL/6 mice
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Dosage:
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2 mg/kg
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Administration:
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Pre-treated (i.p.) 1 h before administration of FBP (100 mg/kg)
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Result:
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Completely prevented the increase of serum adenosine concentration induced by FBP.
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6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-103265B | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
ARL67156 trisodium salt hydrate | 160928-38-1 | 1mg | 1800元 |
| 2024/01/25 | HY-103265B | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
ARL67156 trisodium salt hydrate | 160928-38-1 | 5mg | 6500元 |
6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
生产厂家
160928-38-1, 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 相关搜索:
- ATPase
- C15H24Br2N5O12P3
- C15H21Br2N5O12P33Na
- C15H21Br2N5Na3O12P3
- 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
- 160928-38-1
- 5'-Adenylic acid, N,N-diethyl-, 5'-anhydride with P,P'-(dibromomethylene)bis[phosphonic acid]
- 6-N,N-Diethyl-D-β,γ-dibromomethyleneATPtrisodiumsalt
- 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5'-triphosphate trisodium salt hydrate
- 6-N,N-Diethyl-D-B,G-Dibromomethyleneatp Tri
- 6-N,N-Diethyl-D-beta,gamma-dibromomethyleneATP trisodium salt
- FPL 67156, 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5-triphosphate
- 6-n,n-diethyl-β-γ-dibromomethylene-d-adenosine-5-triphosphate
- 6-N,N-Diethyl-D-b,g-dibromomethyleneATP
- ARL 67156 TRISDODIUM >97% PURITY \ ECTO- ATPASE INHIBITOR
- 6-N,N-DIETHYL-D-B,G-DIBROMOMETHYLENEATP TRISODIUM SALT
- 6-N,N-DIETHYL-D-BETA-GAMMA-DIBROMOMETHYLENE ATP
- 6-N,N-DIETHYL-BETA-GAMMA-DIBROMOMETHYLENE-D-ADENOSINE-5-TRIPHOSPHATE TRISODIUM
- FPL 67156 TRISODIUM
- FPL-67156
- ARL 67156 TRISODIUM SALT
- ARL 67156 TRISODIUM
- ARL-67156
- ARL 67156 trisodium salt hydrate