283172-68-9
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- CAS号:
- 283172-68-9
- 英文名:
- WD2000-012547
- 英文别名:
- WD2000-012547;WD2000 012547,WD2000012547,WD-2000-012547;6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 1,3,4,5-tetrahydro-2-phenyl-
- 中文名:
- 283172-68-9
- 中文别名:
- 化合物 T13333
- CBNumber:
- CB43339729
- 分子式:
- C17H14N2O
- 分子量:
- 262.30586
- MOL File:
- 283172-68-9.mol
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283172-68-9化学性质
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熔点:
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249-255 °C (decomp)
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沸点:
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600.2±44.0 °C(Predicted)
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密度:
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1.270±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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14.94±0.20(Predicted)
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283172-68-9性质、用途与生产工艺
WD2000-012547 是一种选择性的 PARP-1 抑制剂，pKi 为 8.221。
Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pK
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of 8.221.
283172-68-9
上下游产品信息
上游原料
下游产品
283172-68-9, 283172-68-9 相关搜索:
- 化合物 T13333
- 283172-68-9
- WD2000 012547,WD2000012547,WD-2000-012547
- 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 1,3,4,5-tetrahydro-2-phenyl-
- WD2000-012547