283172-68-9
中文名称 | 283172-68-9 |
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中文同义词 | 化合物 T13333 |
英文名称 | WD2000-012547 |
英文同义词 | WD2000-012547;6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 1,3,4,5-tetrahydro-2-phenyl-;WD2000 012547,WD2000012547,WD-2000-012547 |
CAS号 | 283172-68-9 |
分子式 | C17H14N2O |
分子量 | 262.30586 |
EINECS号 | |
相关类别 | |
Mol文件 | 283172-68-9.mol |
结构式 |
283172-68-9 性质
熔点 | 249-255 °C (decomp) |
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沸点 | 600.2±44.0 °C(Predicted) |
密度 | 1.270±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 14.94±0.20(Predicted) |
PARP-1 8.221 (pKi) |
Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pK i of 8.221.