网站主页 >> CAS数据库列表 >> 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
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- CAS号:
- 1482-50-4
- 英文名:
- 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
- 英文别名:
- dihydrocortisol;5B-Dihydrocortisol;52-Dihydrocortisol;5β-Dihydrocortisol;5-BETA-DIHYDROCORTISOL;21-Di[methylenebis(oxy)] 5α5B-pregnane-11B-17A-21-triol-3-20-dione;5β-Pregnane-11β,17α,21-triol-3,20-dione;5β-PREGNAN-11β, 17, 21-TRIOL-3, 20-DIONE;5-BETA-PREGNAN-11-BETA, 17,21-TRIOL-3,20-DIONE
- 中文名:
- 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
- 中文别名:
- 5Β-二氢皮质醇
- CBNumber:
- CB4757474
- 分子式:
- C21H32O5
- 分子量:
- 364.48
- MOL File:
- 1482-50-4.mol
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11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE化学性质
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熔点:
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>173°C (dec.)
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沸点:
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544.5±50.0 °C(Predicted)
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密度:
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1.249±0.06 g/cm3(Predicted)
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储存条件:
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Refrigerator
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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12.50±0.70(Predicted)
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颜色:
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White to Off-White
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11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE性质、用途与生产工艺
5β-Dihydrocortisol，氢化可的松 (Cortisol) 的代谢产物，是潜在的盐皮质激素。5β-Dihydrocortisol 可以增强糖皮质激素的活性以提高眼压。5β-Dihydrocortisol 可引起乳腺癌细胞凋亡。
5β-Dihydrocortisol (10-100 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC
50
of 27.59 μM.
5β-Dihydrocortisol (14 μM; 24 h) induces 35.6% early apoptosis and 2.5% late apoptosis in MCF-7 cells.
5β-Dihydrocortisol (1-10 μM; 48 h) quenches the intrinsic fluorescence of human serum albumin (HAS) with a maximum emission peak at 360 nm, with no shift in fluorescence peak.
Cell Viability Assay
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Cell Line:
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MCF-7 and HEK 293 cells
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Concentration:
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10, 20, 40, 60, 80, 100 μM
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Incubation Time:
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48 hours
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Result:
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Inhibited the viability of MCF-7 cells in a dose-dependent manner.
No toxicity in terms of cell viability was observed with HEK293 cell line.
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Apoptosis Analysis
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Cell Line:
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MCF-7 cells
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Concentration:
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14 μM
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Incubation Time:
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24 hours
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Result:
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Induced 35.6% and 2.5% of early and late apoptosis.
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5β-Dihydrocortisol (0.1-1.0%; 18 d) potentiates the action of topically applied Dexamethasone (0.06%) in raising the intraocular pressure (IOP) in young rabbits.
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-N3995 | 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
5β-Dihydrocortisol | 1482-50-4 | 5mg | 2800元 |
| 2024/01/25 | HY-N3995 | 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
5β-Dihydrocortisol | 1482-50-4 | 10mM * 1mLin DMSO | 3080元 |
11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
生产厂家
1482-50-4, 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE 相关搜索:
- Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
- 5Β-二氢皮质醇
- 1482-50-4
- 5β-PREGNAN-11β, 17, 21-TRIOL-3, 20-DIONE
- Pregnane-3,20-dione, 11,17,21-trihydroxy-, (5β,11β)-
- 5β-Dihydrocortisol
- 21-Di[methylenebis(oxy)] 5&alpha
- 52-Dihydrocortisol
- 5β-Pregnane-11β,17α,21-triol-3,20-dione
- 5B-Dihydrocortisol
- (5R,8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
- 5B-pregnane-11B-17A-21-triol-3-20-dione
- 5-BETA-DIHYDROCORTISOL
- 5BETA-PREGNAN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
- 5-BETA-PREGNAN-11-BETA, 17,21-TRIOL-3,20-DIONE
- 11-BETA,17-ALPHA,21-TRIHYDROXY-5-BETA-PREGNANE-3,20-DIONE
- dihydrocortisol
- 11-beta,17,21-trihydroxy-5-beta-pregnane-3,20-dione
- 11-beta,17,21-trihydroxy-5-beta-pregnane-20-dione
- 11,17,21-trihydroxy-,(5beta,11beta)-pregnane-20-dione