RENTIAPRIL RACEMATE
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- CAS号:
- 72679-47-1
- 英文名:
- rentiapril
- 英文别名:
- SA-446 racemate;Rentiapril (racemate);2-(2'-Hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidine carboxylic acid;2-(2-hydroxyphenyl)-3-(3-sulfanylpropanoyl)-1,3-thiazolidine-4-carboxylic acid;4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-
- 中文名:
- RENTIAPRIL RACEMATE
- 中文别名:
- 伦噻普利外消旋体;伦唑普利外消旋体;化合物 T16731
- CBNumber:
- CB51321949
- 分子式:
- C13H15NO4S2
- 分子量:
- 313.39
- MOL File:
- 72679-47-1.mol
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RENTIAPRIL RACEMATE化学性质
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沸点:
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553.7±50.0 °C(Predicted)
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密度:
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1.451±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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3.02±0.40(Predicted)
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RENTIAPRIL RACEMATE性质、用途与生产工艺
Rentiapril racemate (SA-446 racemate) 是 Rentiapril 的外消旋体。Rentiapril 是一种血管紧张素转换酶 (ACE) 抑制剂。
Angiotensin converting enzyme (ACE)
A three-months toxicity study of an angiotensin converting enzyme (ACE) inhibitor, Rentiapril (CAS 80830-42-8), is performed in Sprague-Dawley rats by oral administration. The dose levels of 0, 30, 125, 500 and 1000 mg/kg are tested in both sexes, in which each experimental group comprised 10 rats. Another ACE inhibitor, captopril, is used as a reference compound. Rentiapril at the highest dose of 1000 mg/kg causes low food consumption and death of some animals with signs of bloody feces and anemia. In males and females receiving 500 and 1000 mg/kg, there are low body weight gain, increases in water intake, urine volume and serum BUN level, and decreases in levels of various erythrocytic parameters. Kidney weight is increased dose-dependently in both sexes. Histopathologically, renal changes in the 500 and 1000 mg/kg groups consist of proximal tubular degeneration, juxtaglomerular cell hyperplasia and interstitial cell infiltration. Similar, but mild, changes in proximal tubules are present in the female 125 mg/kg group. Dead animals from the highest dose groups further show gastrointestinal hemorrhagic erosion and/or ulcer, decrease bone marrow erythropoiesis and hepatocytic vacuolar degeneration. There is no pathological alteration in rats from other Rentiapril-treated groups, as well as in controls. These results indicate that the no-effect dose of Rentiapril in rats by three months oral administration is 30 mg/kg in female and 125 mg/kg in male.
RENTIAPRIL RACEMATE
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-U00074 | RENTIAPRIL RACEMATE Rentiapril racemate | 72679-47-1 | 1 mg | 909元 |
2024/04/30 | HY-U00074 | RENTIAPRIL RACEMATE Rentiapril racemate | 72679-47-1 | 5 mg | 2000元 |
72679-47-1, RENTIAPRIL RACEMATE 相关搜索:
- 化合物 T16731
- 伦噻普利外消旋体
- 伦唑普利外消旋体
- 72679-47-1
- SA-446 racemate
- 2-(2-hydroxyphenyl)-3-(3-sulfanylpropanoyl)-1,3-thiazolidine-4-carboxylic acid
- Rentiapril (racemate)
- 4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-
- 2-(2'-Hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidine carboxylic acid