1,2-脱水肌醇
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- CAS号:
- 6090-95-5
- 英文名:
- CONDURITOL B EPOXIDE
- 英文别名:
- CBE;conduritolepoxide;CONDURITOL B EPOXIDE;CONDURITOL C EPOXIDE;1,2-Anhydro-myo-inositol;Myo-Inositol,1,2-anhydro-;Conduritol B Epoxide (CBE);(+/-) CONDURITOL B EPOXIDE;DL-1,2-ANHYDRO-MYO-INOSITOL;myo-Inositol, 1,2-anhydro- (9CI)
- 中文名:
- 1,2-脱水肌醇
- 中文别名:
- 脱水肌醇;1,2-脱水肌醇;环己烯四醇Β环氧化物;环己烯四醇Β环氧化物(脱水肌醇);REL-(1R,2R,3S,4S,5R,6S)-7-氧杂二环[4.1.0]庚烷-2,3,4,5-四醇
- CBNumber:
- CB5316315
- 分子式:
- C6H10O5
- 分子量:
- 162.14
- MOL File:
- 6090-95-5.mol
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1,2-脱水肌醇化学性质
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熔点:
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157-159
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沸点:
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360.5±42.0 °C(Predicted)
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密度:
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1.925±0.06 g/cm3 (20 ºC 760 Torr)
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储存条件:
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2-8°C
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溶解度:
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Soluble in Water (up to 25 mg/ml) or in DMSO
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酸度系数(pKa):
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13.08±0.70(Predicted)
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形态:
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White solid
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颜色:
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White
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稳定性:
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Moisture Sensitive
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1,2-脱水肌醇性质、用途与生产工艺
Conduritol B epoxide 是一种不可逆的,共价的 β-glucosidase 抑制剂。
Treating N2a and Conduritol B epoxide-N2a cells with G6 gave GC reductions to 7% and 26% of untreated levels, respectively. G6 treated Conduritol B epoxide-N2a also has significantly decreased GS. Co-treatment of G6 and dantrolene of Conduritol B epoxide-N2a cells lead to a similar degree of GC and GS reduction as G6 alone, indicating a specific effect of G6 on inhibition of substrate accumulation, Conduritol B epoxide-N2a cells have higher calcium levels than in N2a cells without caffeine at baseline. Conduritol B epoxide-N2a cells show a significant increase in cytosolic calcium levels compared to N2a cells. Conduritol B epoxide-N2a cells show a significant reduction in OCR as evidenced by approximately 50% in all the parameters, including rate of ATP production, basal respiration, and maximal respiration, compared to N2a cells, indicating reduced mitochondrial function in this nGD cell model. In dantrolene-treated Conduritol B epoxide-N2a cells, levels of Ryr3 are increased to 76% of WT level.
Conduritol B epoxide treatment of 4L, 9H, 9V and WT mice (100 mg/kg/day, i.p.) from postnatal day 5 to 11 does not induce α-synuclein aggregates. Long-term daily Conduritol B epoxide treatment of 4L mice (100 mg/kg/day of Conduritol B epoxide from postnatal day 15 for 24 or 36 doses) leads to hind limb paralysis and small amounts of α-synuclein accumulation in the olfactory bulb, brainstem, and PVP near D3V (dorsal 3rd ventricle).
1,2-脱水肌醇
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-100944 | Conduritol B epoxide | | 1 mg | 250元 |
2024/08/19 | HY-100944 | 1,2-脱水肌醇 Conduritol B epoxide | 6090-95-5 | 5mg | 550元 |
1,2-脱水肌醇
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1,2-脱水肌醇国内生产厂家
6090-95-5, 1,2-脱水肌醇 相关搜索:
- api
- Inhibitors
- Glycosidase Inhibitors
- All Inhibitors
- EPOXYDE
- 药靶配体
- 小分子
- 抑制剂
- Glucosidase, beta-
- D to K
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Enzymes, Inhibitors, and Substrates
- Biochemicals and Reagents
- BioChemical
- REL-(1R,2R,3S,4S,5R,6S)-7-氧杂二环[4.1.0]庚烷-2,3,4,5-四醇
- 环己烯四醇Β环氧化物
- 1,2-脱水肌醇
- 环己烯四醇Β环氧化物(脱水肌醇)
- 脱水肌醇
- 6090-95-5
- rel-(1R,2R,3S,4S,5R,6S)-7-Oxabicyclo[4.1.0]heptane-2,3,4,5-tetraol
- Conduritol B Epoxide (Conduritol Epoxide)
- inhibit,Glucosidase,Inhibitor,Conduritol B epoxide
- CBE
- (1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetraol
- CONDURITOL C EPOXIDE
- Conduritol B Epoxide - CAS 6090-95-5 - Calbiochem
- Myo-Inositol,1,2-anhydro-
- Conduritol B Epoxide (CBE)
- 4h-3,1-benzoxazin-4-one, 5-methyl-2-(3-nitrophenyl)-
- myo-Inositol, 1,2-anhydro- (9CI)
- (1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
- 1,2-Anhydro-myo-inositol
- DL-1,2-ANHYDRO-MYO-INOSITOL
- CONDURITOL B EPOXIDE
- (+/-) CONDURITOL B EPOXIDE
- conduritolepoxide