卡立泊来德
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- CAS号:
- 159138-80-4
- 英文名:
- CARIPORIDE
- 英文别名:
- CS-1692;CARIPORIDE;Cariporide (HOE-642);N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide;BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-;Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642
- 中文名:
- 卡立泊来德
- 中文别名:
- 卡立泊来德;CARIPORIDE,NHE1抑制剂;N-(二氨基亚甲基)-4-异丙基-3-(甲磺酰基)苯甲酰胺;N-(氨基亚氨基甲基)-4-(1-甲基乙基)-3-(甲磺酰基)苯甲酰胺
- CBNumber:
- CB5324031
- 分子式:
- C12H17N3O3S
- 分子量:
- 283.35
- MOL File:
- 159138-80-4.mol
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卡立泊来德化学性质
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熔点:
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90-94° (dec)
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密度:
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1.34
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储存条件:
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2-8°C
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溶解度:
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insoluble in H2O; ≥12.05 mg/mL in DMSO; ≥2.675 mg/mL in EtOH with gentle warming and ultrasonic
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形态:
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powder
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颜色:
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white to beige
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卡立泊来德性质、用途与生产工艺
Cariporide是有效的选择性NHE1抑制剂，在CHO-K1细胞中对hNHE1的IC50值为30 nM。
| Target | Value |
NHE1
(CHO-K1 cells)
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30 nM
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Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na
+
and Ca
2+
accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H
2+
O
2+
. Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca
2+
in cardiac myocytes through inhibition of Na
+
/H
+
exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
Intravenous administration of cariporide significantly decreases brain Na
+
uptake and reduces cerebral edema, brain swelling, and infarct volume.
卡立泊来德
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-19693 | Cariporide | | 1 mg | 250元 |
| 2024/01/25 | HY-19693 | 卡立泊来德
Cariporide | 159138-80-4 | 5mg | 550元 |
159138-80-4, 卡立泊来德 相关搜索:
- Inhibitors
- 药靶配体
- 合成材料中间体
- 小分子抑制剂，天然产物
- 小分子抑制剂
- C12H17N3O3S
- 159138-80-3
- CARIPORIDE,NHE1抑制剂
- N-(二氨基亚甲基)-4-异丙基-3-(甲磺酰基)苯甲酰胺
- N-(氨基亚氨基甲基)-4-(1-甲基乙基)-3-(甲磺酰基)苯甲酰胺
- 卡立泊来德
- 159138-80-4
- Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642
- CS-1692
- Cariporide (HOE-642)
- BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-
- N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
- N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide
- N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide
- CARIPORIDE