3-脱氧葡萄糖醛酮
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- CAS号:
- 4084-27-9
- 英文名:
- 3-DEOXYGLUCOSONE
- 英文别名:
- 3DG;3-DEOXYGLUCOSONE;d-3-deoxyglucosone;3-Deoxy-D-glucosone;2-Keto-3-deoxyglucose;3-Deoxy-D-glucosone ,95%;2-Keto-3-Deoxyglucose-13C;3-Deoxy-D-erythro-hexulose;Glucuronic Acid Impurity 8;3-deoxy-d-erythro-hexosulos
- 中文名:
- 3-脱氧葡萄糖醛酮
- 中文别名:
- 3-葡萄糖醛酮;3-脱氧葡萄糖;3-脱氧葡萄糖醇;3-脱氧葡萄糖酮;3-脱氧葡萄糖醛酮;化合物 T19117;D-葡萄糖醛酸杂质8;3-脱氧-D-葡萄糖酮;3-脱氧-D-葡糖醛酮;3-脱氧-D-葡萄糖酮醛
- CBNumber:
- CB5372027
- 分子式:
- C6H10O5
- 分子量:
- 162.14
- MOL File:
- 4084-27-9.mol
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3-脱氧葡萄糖醛酮化学性质
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熔点:
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73-75°C
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沸点:
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208.81°C (rough estimate)
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密度:
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1.2132 (rough estimate)
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折射率:
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1.4230 (estimate)
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RTECS号:
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MQ3390000
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储存条件:
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Hygroscopic, -20°C Freezer, Under Inert Atmosphere
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溶解度:
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Methanol (Slightly), Water (Slightly, Sonicated)
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形态:
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Solid
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酸度系数(pKa):
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13.17±0.20(Predicted)
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颜色:
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Yellow
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水溶解性:
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Soluble in water, methanol or hot ethanol.
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稳定性:
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Hygroscopic
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3-脱氧葡萄糖醛酮性质、用途与生产工艺
3-Deoxyglucosone (3-Deoxy-D-glucosone) 是美拉德反应和多元醇途径的反应中间体 (intermediate)。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化终产物 (AGEs)，例如咪唑啉酮，它是 3-DG 的最特异 AGE。3-Deoxyglucosone 可以与低葡萄糖协同作用以增强 GLP-1 分泌，可以作为糖尿病生物学检测的标志物。
3-Deoxyglucosone (80 ng/ml-1000 ng/ml; 1 hour) markedly increases GLP-1 secretion by 1.23-folds in 300 ng/ml or 1000 ng/ml 3DG-treated group. But at alower concentration (80 ng/ml) has no effects.3-Deoxyglucosone (300 ng/ml; 1 hour) dramatically increases intracellular Ca
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levels by Fluo-3/AM determination (2.5 μM for 30 mins). But 3DG does not affect intracellular cAMP levels in a cAMP Elisa assay.3-Deoxyglucosone (300 ng/ml; 1 hour) significantly increases the protein expression levels of TAS1R2, TAS1R3, and TRPM5 under both glucose-free and highconditions.
Western Blot Analysis
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Cell Line:
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STC-1 cells
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Concentration:
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300 ng/ml
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Incubation Time:
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1 hour
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Result:
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Upregulated TAS1R2, TAS1R3, and TRPM5 expression.
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3-Deoxyglucosone (intragastric administration; 20 mg/kg; single dose) impairs glucose tolerance with increased AUC, but the plasma glucagon levels are not significantly different. It developes impaired glucose regulation (IGR) with obviously pancreatic islet cell dysfunction in kunming mice and SD-rats.3-deoxyglucosone (gastric gavage; 5-50 mg/kg; once daily; 2 weeks) is significantly increased in the upper small intestine (1.4-fold), lower small intestine (1.4-fold), ileum (1.4-fold) and colon (two fold) compared with the basal levels in the corresponding control group. In addition, the protein expressions of TAS1R2, TAS1R3 and TRPM5 in both duodenum and colon are significantly decreased.
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Animal Model:
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SD rats
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Dosage:
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5, 20 and 50 mg/kg
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Administration:
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oral administration; once daily; 2 weeks
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Result:
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Was capable of accumulating in intestinal tissue and thereby decreased secretion of GLP-1 and insulin.
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3-脱氧葡萄糖醛酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-N7426 | 3-Deoxyglucosone | | 1 mg | 2320元 |
| 2024/01/25 | HY-N7426 | 3-脱氧葡萄糖醛酮
3-Deoxyglucosone | 4084-27-9 | 5 mg | 5800元 |
4084-27-9, 3-脱氧葡萄糖醛酮 相关搜索:
- Intermediates
- Carbohydrates & Derivatives
- aldehydes
- 13C & 2H Sugars
- 4084-47-9
- D-葡萄糖醛酸杂质8
- 3-脱氧-D-葡萄糖酮
- 3-脱氧-D-[UL-13C6]葡萄糖酮
- 化合物 T19117
- 3-脱氧葡萄糖酮
- 3-脱氧葡萄糖醛酮
- 3-脱氧葡萄糖
- 3-脱氧葡萄糖醇
- 3-脱氧-D-葡萄糖酮醛
- 3-葡萄糖醛酮
- 3-脱氧-D-葡糖醛酮
- 4084-27-9
- 3-deoxy-D-[UL-13C6]glucosone
- Glucuronic Acid Impurity 8
- D-erythro-Hexos-2-ulose, 3-deoxy-
- Fructose Glycerol Derivative 6 (3-Deoxyglucosone)
- 3-Deoxy-D-glucosone, Min. 95%
- 3-Deoxy-D-erythro-hexosulose
- 3-Deoxy-D-erythro-hexulose-13C
- 2-Keto-3-Deoxyglucose-13C
- 3-Deoxy-D-erythro-hexulose
- 2-Keto-3-deoxyglucose
- (4S,5R)-2-Oxo-4,5,6-trihydroxyhexan-1-one
- 3-Deoxy-D-glucosone ,95%
- 3-Deoxy-D-glucosone
- 3-Deoxy-D-erythro-Hexulose 2-Keto-3-Deoxyglucose 3DG
- (4S,5R)-4,5,6-trihydroxy-2-oxo-hexanal
- (4S,5R)-4,5,6-trihydroxy-2-oxohexanal
- (4S,5R)-4,5,6-trihydroxy-2-keto-hexanal
- 3-Deoxy-D-erythro-2-hexosulose
- 3-Deoxy-D-arabino-2-hexosulose
- 3-DEOXYGLUCOSONE
- 3-DEOXY-D-ERYTHRO-HEXULOSE2-KETO-3-DEOXYGLUCOSE
- 3DG
- d-3-deoxyglucosone
- 3-deoxy-d-erythro-hexosulos
- 3-deoxy-d-erythro-hexos-2-ulose