AMPHOTERICIN B TRIHYDRATE
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- CAS号:
- 1397-89-3
- 英文名:
- AMPHOTERICIN B TRIHYDRATE
- 英文别名:
- AMPHOTERICIN B TRIHYDRATE
- 中文名:
- 中文别名:
- CBNumber:
- CB5414057
- 分子式:
- C47H79NO20
- 分子量:
- 978.12
- MOL File:
- Mol file
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AMPHOTERICIN B TRIHYDRATE化学性质
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储存条件:
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2-8°C
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颜色:
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Deep-yellow prisms from DMF
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AMPHOTERICIN B TRIHYDRATE性质、用途与生产工艺
Amphotericin B trihydrate 是一种多烯抗生素,最初是从 Streptomyces nodosus 发酵菌种分离出来,具有抗利什曼虫的活性。
Amphotericin B interacts with cholesterol, the major sterol of mammal membranes, thus limiting the usefulness of Amphotericin B due to its relatively high toxicity. Amphotericin B is dispersed as a pre-micellar or as a highly aggregated state in the subphase. Amphotericin B only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. Amphotericin B (0.1 mM) induces a polarization potential, indicating K
+
leakage in KCl-loaded liposomes suspended in an iso-osmotic sucrose solution. Amphotericin B (0.05 mM) exhibits a nearly total collapse of the negative membrane potential, indicating Na
+
entry into the cells.
Amphotericin B results in prolonging the incubation time and decreasing PrPSc accumulation in the hamster scrapie model. Amphotericin B markedly reduces PrPSc levels in mice with transmissible subacute spongiform encephalopathies (TSSE). Amphotericin B exerts a direct effect on Plasmodium falciparum and influences eryptosis of infected erythrocytes, parasitemia and hostsurvival in murine malaria. Amphotericin B tends to delay the increase of parasitemia and significantly delays host death plasmodium berghei-infected mice.
AMPHOTERICIN B TRIHYDRATE
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AMPHOTERICIN B TRIHYDRATE
生产厂家
1397-89-3, AMPHOTERICIN B TRIHYDRATE 相关搜索:
- 1397-89-3 (ANHYDROUS)
- AMPHOTERICIN B TRIHYDRATE