索利那新盐酸盐
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- CAS号:
- 180468-39-7
- 英文名:
- Solifenacin Hydrochloride
- 英文别名:
- Solifenacin HCl;YM905 hydrochloride;YM-905 hydrochloride;YM 905 hydrochloride;Vesicare hydrochloride;Solifenacin Succinate 3;Solifenacin Hydrochloride;VESICARE HYDROCHLORIDE;YM905 HYDROCHLORIDE;YM 905 HYDROCHLORIDE;YM-905 HYDROCHLORIDE;(1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid (3R)-1-Azabicyclo-[2.2.2]oct-3-yl Ester Hydrochlorid;(1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid (3R)-1-Azabicyclo-[2.2.2]oct-3-yl Ester Hydrochloride
- 中文名:
- 索利那新盐酸盐
- 中文别名:
- 索利那新盐酸盐;化合物 T23379
- CBNumber:
- CB61176791
- 分子式:
- C23H27ClN2O2
- 分子量:
- 398.93
- MOL File:
- 180468-39-7.mol
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索利那新盐酸盐化学性质
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熔点:
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120-122°C
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储存条件:
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Hygroscopic, -20°C Freezer, Under Inert Atmosphere
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溶解度:
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DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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索利那新盐酸盐性质、用途与生产工艺
Solifenacin hydrochloride (YM905 hydrochloride) 是毒蕈碱受体 (muscarinic receptor) 拮抗剂，对 M1，M2 和 M3 受体的 pKi 值分别为 7.6, 6.9 和 8.0。
Solifenacin hydrochloride (YM905 hydrochloride) is a novel muscarinic receptor antagonist with pK
i
s of 7.6±0.056, 6.9±0.034 and 8.0±0.021 for M1, M2 and M3 receptors, respectively. In murine submandibular gland cells, the antagonistic effects of 100 nM Solifenacin hydrochloride and oxybutynin on Ca
2+
mobilization evoked by varying doses of carbachol (CCh) are examined. Solifenacin hydrochloride does not shift the CCh dose-activation curve in a parallel manner whereas oxybutynin shows insurmountable antagonism. The pK
b
values are obtained as 7.4±0.17 for Solifenacin hydrochloride and 8.8±0.21 for oxybutynin.
Solifenacin hydrochloride (YM905 hydrochloride) reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg). In contrast, its inhibitory effects on salivary and cardiac responses are only slight at 630 nmol/kg (0.3 mg/kg), and reach 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). At doses of 63 and 210 nmol/kg (0.03 and 0.1 mg/kg), Solifenacin hydrochloride slightly increases saliva secretion. Solifenacin hydrochloride (0.01 to 0.3 mg/kg i.v.) dose-dependently increases bladder capacity and voided volume at doses of 0.03 mg/kg i.v. or more, but does not affect residual volume or micturition pressure at any dose tested.
索利那新盐酸盐
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-I0230 | 索利那新盐酸盐
Solifenacin hydrochloride | 180468-39-7 | 5mg | 950元 |
| 2024/04/30 | HY-I0230 | 索利那新盐酸盐
Solifenacin hydrochloride | 180468-39-7 | 10mM * 1mLin DMSO | 1045元 |
180468-39-7, 索利那新盐酸盐 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- C23H27ClN2O2
- 化合物 T23379
- 索利那新盐酸盐
- 180468-39-7
- Solifenacin HCl
- YM-905 hydrochloride
- YM905 hydrochloride
- YM 905 hydrochloride
- VESICARE HYDROCHLORIDE;YM905 HYDROCHLORIDE;YM 905 HYDROCHLORIDE;YM-905 HYDROCHLORIDE
- Vesicare hydrochloride
- Solifenacin Succinate 3
- (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid (3R)-1-Azabicyclo-[2.2.2]oct-3-yl Ester Hydrochloride
- Solifenacin Hydrochloride
- (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic acid (3R)-1-azabicyclo[2.2.2]oct-3-yl ester hydrochloride (1:1)
- (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid (3R)-1-Azabicyclo-[2.2.2]oct-3-yl Ester Hydrochlorid