BRD9539
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- CAS号:
- 1374601-41-8
- 英文名:
- BRD-9539
- 英文别名:
- BRD9539;BRD 9539;BRD-9539;2-Benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylic acid;2-(BenzoylaMino)-1-(3-phenylpropyl)-1H-benziMidazole-5-carboxylic acid;1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-;Histone Methyltransferase,chromatin,PRC2,BRD9539,G9a,senescent,BRD-9539,BRD 9539,inhibit,H3K9,histones,Inhibitor,EHMT2
- 中文名:
- BRD9539
- 中文别名:
- PRC2抑制剂;化合物BRD9539;G9A和PRC2抑制剂(BRD9539);2-苯甲酰胺基-1-(3-苯基丙基)-1H-苯并[D]咪唑-5-羧酸
- CBNumber:
- CB62667164
- 分子式:
- C24H21N3O3
- 分子量:
- 399.44
- MOL File:
- 1374601-41-8.mol
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BRD9539化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble15mg/mL, clear
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形态:
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powder
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颜色:
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white to beige
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BRD9539性质、用途与生产工艺
BRD9539 是一种组蛋白甲基转移酶 G9a 抑制剂，IC50 为 6.3 μM。BRD9539 还抑制 PRC2 活性，并且对 SUV39H1，NSD2 和 DNMT1 无活性。
BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.
BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.
BRD9539
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-15647 | BRD9539
BRD9539 | 1374601-41-8 | 5mg | 600元 |
| 2024/01/25 | HY-15647 | BRD9539
BRD9539 | 1374601-41-8 | 10mM * 1mLin DMSO | 660元 |
1374601-41-8, BRD9539 相关搜索:
- 对照品
- 细胞生物学试剂
- PRC2抑制剂
- 2-苯甲酰胺基-1-(3-苯基丙基)-1H-苯并[D]咪唑-5-羧酸
- 化合物BRD9539
- G9A和PRC2抑制剂(BRD9539)
- 1374601-41-8
- Histone Methyltransferase,chromatin,PRC2,BRD9539,G9a,senescent,BRD-9539,BRD 9539,inhibit,H3K9,histones,Inhibitor,EHMT2
- 2-Benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylic acid
- 1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-
- 2-(BenzoylaMino)-1-(3-phenylpropyl)-1H-benziMidazole-5-carboxylic acid
- BRD-9539
- BRD9539
- BRD 9539