MVPQJUFFTWWKBT-LBDWYMBGSA-N
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- CAS号:
- 210344-97-1
- 英文名:
- MVPQJUFFTWWKBT-LBDWYMBGSA-N
- 英文别名:
- MVPQJUFFTWWKBT-LBDWYMBGSA-N;Caspase 4,Inhibitor,Anti-inflammatory,ZYVADFMK,Caspase 1,Z YVAD FMK,Caspase,inhibit,anti-tumor;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-tyrosyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- (9CI)
- 中文名:
- MVPQJUFFTWWKBT-LBDWYMBGSA-N
- 中文别名:
- 606210;化合物Z-YVAD-FMK
- CBNumber:
- CB63554494
- 分子式:
- C31H39FN4O9
- 分子量:
- 630.66
- MOL File:
- 210344-97-1.mol
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MVPQJUFFTWWKBT-LBDWYMBGSA-N化学性质
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沸点:
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945.2±65.0 °C(Predicted)
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密度:
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1.261±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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9.81±0.15(Predicted)
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MVPQJUFFTWWKBT-LBDWYMBGSA-N性质、用途与生产工艺
Z-YVAD-FMK 是一种具有抗炎和抗肿瘤活性的细胞渗透性的、不可逆的 caspase-1 特异性抑制剂。
Z-YVAD-FMK (100 μM; 24 hours) significantly downregulated the growth inhibition induced by butyrate in Caco-2 cells.
Z-YVAD-FMK (20 μM; pre 1 hour; 24 hours) attenuates the apoptotic induction of III-10 on both HepG2 and BEL-7402 cells, the apoptotic rate of -10 on HepG2 cells is reduced by Z-VAD-FMK from 19.88% to 8.34%, while that on BEL-7402 cells is reduced from 17.56% to 11.98%.
Z-YVAD-FMK (1-10 μM; 24 hours) shows inhibitory effect in various cells against TNFr- or anti-CD95-induced cell death, exhibits IC
50
values of 0.0015 μM (Murine hepatocytes), 0.027 μM (Murine hepatocytes), 4.8 μM (HepG2), 5.8 μM (HepG2), 1.6 μM (Hela) and 1.1 μM (Jurkat), respectively.
Cell Viability Assay
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Cell Line:
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Caco-2 cells
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Concentration:
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0-100 μM
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Incubation Time:
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24 hours
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Result:
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Inhibited Caco-2 cells growth.
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Apoptosis Analysis
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Cell Line:
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BEL-7402 and HepG2 cells
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Concentration:
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20 μM
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Incubation Time:
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Pre 1 hour; 24 hours
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Result:
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Induced a caspase-dependent apoptosis in cells.
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Z-VAD-FMK (intraperitoneal injection; 10mg/kg; pre- 30 minutes) significantly delayed preterm delivery at 18 hours, but after 36 hours treatment, non different exists between Z-VAD-FMK-pretreated and control groups.
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Animal Model:
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Day 14.5 pregnant CD1 mice
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Dosage:
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10 mg/kg
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Administration:
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Intraperitoneal injection; 10mg/kg; pre-30 minutes
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Result:
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Prevented HK-GBS-induced preterm delivery.
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MVPQJUFFTWWKBT-LBDWYMBGSA-N
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S8507 | MVPQJUFFTWWKBT-LBDWYMBGSA-N
Z-YVAD-FMK | 210344-97-1 | 5mg | 4370元 |
| 2024/04/30 | S8507 | Z-YVAD-FMK | 210344-97-1 | 10mM (1mL in DMSO) | 5135.13元 |
MVPQJUFFTWWKBT-LBDWYMBGSA-N
生产厂家
210344-97-1, MVPQJUFFTWWKBT-LBDWYMBGSA-N 相关搜索:
- \t抑制剂
- 606210
- 化合物Z-YVAD-FMK
- 210344-97-1
- Caspase 4,Inhibitor,Anti-inflammatory,ZYVADFMK,Caspase 1,Z YVAD FMK,Caspase,inhibit,anti-tumor
- L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-tyrosyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- (9CI)
- MVPQJUFFTWWKBT-LBDWYMBGSA-N