阿瑞洛莫
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- CAS号:
- 289893-25-0
- 英文名:
- (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
- 英文别名:
- Pefcalcitol;Amrioclomol;arimoclomol;BRX-220 free base;(2R-)Arimoclomol NEW;(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol;3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide;aggregation,Heat shock proteins,HSP,co-inducer,system,BRX220,motor,Arimoclomol,inhibit,ubiquitin,BRX 220,neurons,misfolded,proteasome,BRX-220,protein,assemblies,clearance,Inhibitor
- 中文名:
- 阿瑞洛莫
- 中文别名:
- 阿瑞洛莫;阿瑞莫洛;化合物 T13553;N-[((2R)-2-羟基-3-(1-哌啶基)丙氧基]-3-吡啶甲酰亚胺基氯 1-氧化物
- CBNumber:
- CB71480024
- 分子式:
- C14H20ClN3O3
- 分子量:
- 313.78
- MOL File:
- 289893-25-0.mol
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阿瑞洛莫化学性质
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熔点:
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93 - 95o C
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沸点:
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539.2±60.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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储存条件:
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Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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14.03±0.20(Predicted)
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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阿瑞洛莫性质、用途与生产工艺
Arimoclomol (BRX-220 free base) 是一种热休克蛋白 (HSP) 的共诱导剂。Arimoclomol 通过增强 Hsp 表达来保护运动神经元，从而通过泛素-蛋白酶体系统直接影响蛋白质聚集及清除错误折叠和装配的蛋白。
Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis.
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Animal Model:
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Male Wistar rats weighing 240 to 270 g
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Dosage:
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20 mg/kg
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Administration:
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Administered intragastrically, for 5 days
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Result:
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Had a protective effect against CCK-induced acute pancreatitis.
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阿瑞洛莫
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289893-25-0, 阿瑞洛莫 相关搜索:
- 化工试剂
- 阿瑞莫洛
- 化合物 T13553
- N-[((2R)-2-羟基-3-(1-哌啶基)丙氧基]-3-吡啶甲酰亚胺基氯 1-氧化物
- 阿瑞洛莫
- 289893-25-0
- aggregation,Heat shock proteins,HSP,co-inducer,system,BRX220,motor,Arimoclomol,inhibit,ubiquitin,BRX 220,neurons,misfolded,proteasome,BRX-220,protein,assemblies,clearance,Inhibitor
- 3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide
- BRX-220 free base
- (2R-)Arimoclomol NEW
- Pefcalcitol
- Amrioclomol
- arimoclomol
- (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol