几夫碱
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- CAS号:
- 109944-15-2
- 英文名:
- KIFUNENSINE
- 英文别名:
- FR 900494;Kifunensin;KIFUNENSINE;Kifunensine min. 99%;[5R-(5α,6β,7α,8α,8aα)]-;Kifunensine, (+)- - FR 900494;KIFUNENSINE, KITASATOSPORIA KIFUNENSE;Kifunensine, Kitasatosporia kifunense - CAS 109944-15-2 - Calbiochem;Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione;(5R,6R,7S,8R,8AS)-6,7,8-trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione
- 中文名:
- 几夫碱
- 中文别名:
- 几夫碱;贵船能碱;化合物 T20628;13C2,15N]-奇夫能辛
- CBNumber:
- CB7233173
- 分子式:
- C8H12N2O6
- 分子量:
- 232.19
- MOL File:
- 109944-15-2.mol
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几夫碱化学性质
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熔点:
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>280°C
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密度:
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1.85±0.1 g/cm3(Predicted)
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储存条件:
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−20°C
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溶解度:
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water, double-distilled: soluble50MM
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形态:
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White solid
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酸度系数(pKa):
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9.61±0.70(Predicted)
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颜色:
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White
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水溶解性:
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Soluble to 5 mM in water with sonication
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稳定性:
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Desiccate and Store at -20°C
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几夫碱性质、用途与生产工艺
Kifunensine 是可从放线菌中分离得到的 I 类 α-mannosidases 有效选择性抑制剂,可阻断 α-mannosidases I 修剪糖蛋白上的甘露糖残基。Kifunensine 可抑制内质网相关蛋白降解途径。
Kifunensine, an alkaloid from actinomycete Kitasatosporia kifunense 9482, is the most efficient nhibitor of a-mannosidase I, blocking N-glycan synthesis at an8GlcNAc
2
(Man8) or Man9GlcNAc
2
(Man9) stage.
RT-PCR.
Cell Line:
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Hybridoma cells expressing a human IgG1 monoclonal Antibody
[3]
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Concentration:
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2 μg/mL.
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Incubation Time:
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4 days.
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Result:
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Significantly reduced the lentil lectin binding.
Kifunensine is the most effective among the inhibitors tested in producing antibodies containing oligomannose residues without fucose.
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Animal Model:
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BALB/c mice.
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Dosage:
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5 mg/kg.
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Administration:
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IV via tail vein.
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Result:
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There was no significant difference in the serum levels of anti-TEM B mAb generated from cells treated with or without kifunensine in the 7-day period.
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几夫碱
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/01/25 | HY-19332 | 几夫碱 Kifunensine | 109944-15-2 | 5mg | 3000元 |
2024/01/25 | HY-19332 | 几夫碱 Kifunensine | 109944-15-2 | 10mM * 1mLin DMSO | 3300元 |
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109944-15-2, 几夫碱 相关搜索:
- Inhibitors
- Glycosidase Inhibitors
- All Inhibitors
- Antibiotics
- 药靶配体
- 抗体-二抗
- C8H12N2O6
- 贵船能碱
- 13C2,15N]-奇夫能辛
- 化合物 T20628
- 几夫碱
- 109944-15-2
- Kifunensine, (+)- - FR 900494
- Kifunensine, Kitasatosporia kifunense - CAS 109944-15-2 - Calbiochem
- Kifunensin
- KIFUNENSINE
- (5R,6R,7S,8R,8AS)-6,7,8-trihydroxy-5-(hydroxymethyl)hexahydroimidazo[1,2-a]pyridine-2,3-dione
- Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
- FR 900494
- Kifunensine min. 99%
- [5R-(5α,6β,7α,8α,8aα)]-
- (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
- (5R,8aS)-1,5,6,7,8,8a-Hexahydro-6β,7α,8α-trihydroxy-5α-(hydroxymethyl)imidazo[1,2-a]pyridine-2,3-dione
- FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione
- Imidazo1,2-apyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)-
- KIFUNENSINE, KITASATOSPORIA KIFUNENSE