5-氯噻吩-2-甲酰甲胺
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- CAS号:
- 97799-98-9
- 英文名:
- 2-ThiophenecarboxaMide, 5-chloro-N-Methyl-
- 英文别名:
- Rivaroxaban K;Rivaroxaban impurity P2-S;Rivaroxaban CMTCA Impurity;5-Chloro-N-methylthiophene-2-carboxamide;5-chloro-N-methyl-2-thiophenecarboxamide;2-Thiophenecarboxamide, 5-chloro-N-methyl-;5-chloro-2-thiophenecarboxylic acid N-methylamide;Rivaroxaban Impurity E/ Rivaroxaban CMTCA Impurity;Rivaroxaban impurity N: 5-chlorothiophene-2-carboxamide;Imp. D:5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide
- 中文名:
- 5-氯噻吩-2-甲酰甲胺
- 中文别名:
- 利伐沙班杂质D;利伐沙班杂质91;利伐沙班杂质93;利伐沙班杂质P2-S;利伐沙班CMTCA杂质;5-氯噻吩-2-甲酰甲胺;5-氯-N-甲基噻吩-2-甲酰胺;利伐沙班杂质:5-氯噻吩-2-甲酰甲胺;利伐沙班杂质N:5-氯噻吩-2-甲酰胺;利伐沙班杂质G (5-氯噻吩-2-甲酰甲胺)
- CBNumber:
- CB72707364
- 分子式:
- C6H6ClNOS
- 分子量:
- 175.64
- MOL File:
- 97799-98-9.mol
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5-氯噻吩-2-甲酰甲胺化学性质
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熔点:
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164-166°C
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储存条件:
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Refrigerator
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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5-氯噻吩-2-甲酰甲胺性质、用途与生产工艺
5-氯噻吩-2-甲酰甲胺是利伐沙班合成中的杂质D。利伐沙班是抗凝血药,是一种高选择性,直接抑制因子Xa的口服药物,抑制凝血酶的产生和血栓形成。
步骤①向反应器皿D中加入5-氯噻吩-2-甲酸,二氯甲烷,0℃下滴加二氯亚砜,滴加完毕后,室温搅拌4小时;
步骤②之后0℃滴加质量浓度为40%甲胺的水溶液,滴加完毕,室温搅拌18小时;
步骤③之后抽滤,滤饼鼓风55℃干燥至恒重,的固体即为5-氯噻吩-2-甲酰甲胺;
5-氯噻吩-2-甲酸,二氯甲烷,二氯亚砜,40%甲胺的水溶液的加入量为20g,500ml,49.52g,107.73g;
5-氯噻吩-2-甲酰甲胺为10g,收率为41.03%,纯度为99.80%。
5-氯噻吩-2-甲酰甲胺
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | XW029779998905 | 利伐沙班杂质K 5-Chloro-2-thiophenecarboxylic acid N-methylamide | | 1g | 430元 |
2024/08/19 | XW029779998904 | 5-氯-N-甲基噻吩-2-甲酰胺(利伐沙班杂质) | 97799-98-9 | 100MG | 280元 |
97799-98-9, 5-氯噻吩-2-甲酰甲胺 相关搜索:
- 化工试剂
- 产品-医药产品
- 杂化
- 对照品-杂质对照品
- 杂质对照品
- 利伐沙班杂质G (5-氯噻吩-2-甲酰甲胺)
- 5-氯-N-甲基噻吩-2-甲酰胺(利伐沙班杂质)
- 5-氯噻吩-2-甲酰甲胺
- 利伐沙班杂质91
- 利伐沙班杂质93
- 利伐沙班CMTCA杂质
- 利伐沙班杂质:5-氯噻吩-2-甲酰甲胺
- 利伐沙班杂质N:5-氯噻吩-2-甲酰胺
- 5-氯-N-甲基噻吩-2-甲酰胺
- 利伐沙班杂质D
- 利伐沙班杂质P2-S
- 97799-98-9
- 5-chloro-N-methyl-2-thiophenecarboxamide
- Rivaroxaban Impurity E/ Rivaroxaban CMTCA Impurity
- 5-Chloro-N-methylthiophene-2-carboxamide (Rivaroxaban Impurity)
- 2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ISO 9001:2015 REACH
- Rivaroxaban CMTCA Impurity
- Rivaroxaban impurity N: 5-chlorothiophene-2-carboxamide
- Rivaroxaban Impurity 18/5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide
- 5-Chloro-N-methylthiophene-2-carboxamide
- Rivaroxaban K
- 2-Thiophenecarboxamide, 5-chloro-N-methyl-
- 5-chloro-2-thiophenecarboxylic acid N-methylamide
- Rivaroxaban impurity P2-S
- Imp. D:5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide
- Rivaroxaban Related Compound (5-Chloro-2-Thiophenecarboxylic Acid N-Methylamide)
- 2-ThiophenecarboxaMide, 5-chloro-N-Methyl- ExperiMental Properties