红陪酚
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- CAS号:
- 569-77-7
- 英文名:
- PURPUROGALLIN
- 英文别名:
- C09964;MLS0007;NSC 35676;NSC 646653;AIDS138915;CHEBI:8647;AIDS-138915;AKOS 209-004;KBio1_001351;KBio2_000828
- 中文名:
- 红陪酚
- 中文别名:
- 红陪酚;红倍酚;1,2,3,9-四羟基苯并[7]环庚烯-8-酮;1,2,3,9-四羟基-8-苯并[7]环庚烯酮;5H-苯并环庚烯-5-酮,2,3,4,6-四羟基-;2,3,4,6-四羟基-5H-苯并[A]环庚烯-5-酮;2,3,4,6-四羟基-5H-苯并[7]环庚烯-5-酮
- CBNumber:
- CB7329636
- 分子式:
- C11H8O5
- 分子量:
- 220.18
- MOL File:
- 569-77-7.mol
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红陪酚化学性质
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熔点:
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275 °C (dec.)(lit.)
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沸点:
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321.11°C (rough estimate)
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密度:
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1.3824 (rough estimate)
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折射率:
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1.5140 (estimate)
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储存条件:
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−20°C
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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6.75±0.20(Predicted)
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颜色:
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Very Dark Brown
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Merck:
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7946
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稳定性:
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Air Sensitive
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LogP:
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2.050 (est)
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红陪酚性质、用途与生产工艺
Purpurogallin 是从栎属植物中提取的天然酚，具有强的黄嘌呤氧化酶 (Xanthine Oxidase) 抑制活性，其 IC50 为 0.2 µM。Purpurogallin 具有抗氧化和抗炎作用。
IC50: 0.2 µM (xanthine oxidase)
Purpurogallin (50 or 100 µM; 7 or 25 hours; BV2 murine microglial cells) treatment attenuates the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression in LPS-stimulated BV2 microglial cells.
Purpurogallin (100 µM; 75-120 minutes; BV2 murine microglial cells) exhibits anti-inflammatory properties by suppressing the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways in LPS-stimulated BV2 microglial cells.
RT-PCR
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Cell Line:
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BV2 murine microglial cells
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Concentration:
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50 or 100 µM
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Incubation Time:
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7 or 25 hours
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Result:
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Attenuated the production of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) by suppressing their mRNA and protein expression.
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Western Blot Analysis
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Cell Line:
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BV2 murine microglial cells
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Concentration:
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100 µM
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Incubation Time:
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75 minutes, 90 minutes, 120 minutes
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Result:
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Suppressed the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase signaling pathways.
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Purpurogallin (100-400 μg/kg; intraperitoneal injection; for 48 or 72 hours; male Sprague-Dawley rats) exerts its neuroinflammation effect through the dual effect of inhibiting IL-6 and TNF-α mRNA expression and reducing HMGB1 protein and mRNA expression.
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Animal Model:
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Fifty-four male Sprague-Dawley rats (250-350 g) with subarachnoid hemorrhage (SAH)
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Dosage:
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100 μg/kg, 200 μg/kg, 400 μg/kg
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Administration:
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Intraperitoneal injection; for 48 or 72 hours
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Result:
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Dose-dependently reduced HMGB1 protein expression. High dose reduced TNF-α and HMGB1 mRNA levels.
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红陪酚
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-12136 | Purpurogallin | | 1 mg | 228元 |
| 2024/01/25 | HY-12136 | 红陪酚
Purpurogallin | 569-77-7 | 5mg | 600元 |
红陪酚
生产厂家
全球有 53家供应商
红陪酚国内生产厂家
569-77-7, 红陪酚 相关搜索:
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- 1,2,3,9-四羟基苯并[7]环庚烯-8-酮
- 1,2,3,9-四羟基-8-苯并[7]环庚烯酮
- 5H-苯并环庚烯-5-酮,2,3,4,6-四羟基-
- 2,3,4,6-四羟基-5H-苯并[A]环庚烯-5-酮
- 2,3,4,6-四羟基-5H-苯并[7]环庚烯-5-酮
- 红陪酚
- 红倍酚
- 569-77-7
- Inhibitor,inhibit,Purpurogallin,Xanthine Oxidase
- 2,3,4,5-tetrahydroxy-6-benzo[7]annulenone
- 5H-Benzocyclohepten-5-one, 2,3,4,6-tetrahydroxy-
- Spectrum4_001547
- SPECTRUM210505
- Spectrum2_000582
- Spectrum_000348
- SPBio_000424
- SDCCGMLS-0066536.P001
- Oprea1_685478
- NCGC00095229-02
- NCGC00095229-01
- MLS0007
- KBioSS_000828
- KBio3_001663
- KBio2_005964
- KBio2_003396
- KBio2_000828
- KBio1_001351
- DivK1c_006407
- CHEBI:8647
- C09964
- AIDS-138915
- AIDS138915
- PURPUROGALLIN, TECH.
- 2,3,4,6-Tetrahydroxy-5H-benzo[a]cyclohepten-5-one
- 2,3,4,6-tetrahydroxy-5H-benzo[7]annulen-5-one
- 1,2,3,9-tetrahydroxybenzo[7]annulen-8-one
- 1,2,3,9-tetrahydroxy-8-benzo[7]annulenone
- NSC 646653
- NSC 35676
- BENZOCYCLOHEPTENE-5-ONE,2,3,4,6-TETRAHYDROXY-
- PURPUROGALLINE
- PURPUROGALLIN(RG)
- PURPUROGALLIN
- AKOS 209-004
- 2,3,4,6-TETRAHYDROXY-BENZOCYCLOHEPTEN-5-ONE
- 2,3,4,6-tetrahydroxy-5h-benzocycloheptene-5-one
- 2,3,4,6-tetrahydroxy-5h-benzocycloheptene-5-on