Orexin B, human TFA
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- CAS号:
- 英文名:
- Orexin B, human TFA
- 英文别名:
- Orexin B, human TFA
- 中文名:
- Orexin B, human TFA
- 中文别名:
- 内源性激动剂H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
- CBNumber:
- CB75419798
- 分子式:
- C???H???N??O??S.C?HF?O?
- 分子量:
- 0
- MOL File:
- Mol file
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Orexin B, human TFA性质、用途与生产工艺
Orexin B, human (TFA) 是 Orexin 受体的内源性激动剂，与OX1和OX2结合的 Ki 值分别为 420 和 36 nM。
Ki: 420 nM (OX1), 36 nM (OX2).
Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor.
Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC
50
of 36 nM in the binding assay and an EC
50
of 60 nM in the [Ca
2+
]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC
50
in the competitive binding assay and the EC
50
in the [Ca
2+
]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.
Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.
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Animal Model:
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Male Wistar rats (180-200 g).
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Dosage:
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3 nM and 30 nM.
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Administration:
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Administered in a 5 mL bolus through a catheter placed in the left lateral ventricle in early light phase.
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Result:
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Significantly augmented food intake.
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Orexin B, human TFA
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Orexin B, human TFA 试剂级价格
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-P1339A | Orexin B, human TFA
Orexin B, human TFA | | 1mg | 805元 |
| 2024/04/30 | HY-P1339A | Orexin B, human TFA
Orexin B, human TFA | | 5mg | 2030元 |
Orexin B, human TFA 相关搜索:
- 目录多肽
- 内源性激动剂H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
- Orexin B, human TFA