甲磺酸厄洛替尼
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- CAS号:
- 248594-19-6
- 英文名:
- ERLOTINIB MESYLATE
- 英文别名:
- CP-358;ERLOTINIB MESYLATE;Erlotinib (OSI-744) mesylate;Erlotinib mesylate
(CP-358774;CP-358774;OSI-774;NSC 718781;R 1415;TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415
- 中文名:
- 甲磺酸厄洛替尼
- 中文别名:
- 甲磺酸埃罗替尼;甲磺酸厄洛替尼;埃罗替尼甲磺酸盐;化合物 T0373L1
- CBNumber:
- CB7677124
- 分子式:
- C23H27N3O7S
- 分子量:
- 489.54
- MOL File:
- 248594-19-6.mol
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甲磺酸厄洛替尼化学性质
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储存条件:
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Store at -20°C
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溶解度:
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25℃: DMSO
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形态:
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Powder
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甲磺酸厄洛替尼性质、用途与生产工艺
Erlotinib mesylate (CP-358774 mesylate) 为 EGFR 抑制剂,IC50 值为 2 nM。
Erlotinib mesylate (CP-358774 mesylate) is also a potent inhibitor of the recombinant intracellular (kinase) domain of the EGFR, with an IC
50
of 1 nM. The proliferation of DiFi cells is strongly inhibited by Erlotinib with an IC
50
of 100 nM for an 8-day proliferation assay. The combination of B-DIM and Erlotinib (2 μM) results in a significant inhibition of colony formation in BxPC-3 cells when compared with either agent alone. The combination of B-DIM and Erlotinib (2 μM) results in a significant induction of apoptosis only in BxPC-3 cells when compare with the apoptotic effect of either agent alone.
There is a 1.49-fold statistically significant difference between AUC
0-inf
after p.o. administration of Erlotinib (5 mg/kg) comparing Bcrp1/Mdr1a/1b
-/-
and WT mice (7,419±1,720 versus 4,957±1,735 ng*h/mL respectively, P=0.01). The administration of Erlotinib (10 mg/kg/day, or 20 mg/kg/day) to Bleomycin (BLM)-treated rats shows no exacerbation of lung injuries in indices such as macroscopic findings, lung weights, histopathological scores (lung lesion density and lung fibrosis score), and pulmonary hydroxyproline (HyP) level. The result suggests that Erlotinib does not have any exacerbating effects on lung injuries induced by BLM in rats.
甲磺酸厄洛替尼
上下游产品信息
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248594-19-6, 甲磺酸厄洛替尼 相关搜索:
- 甲磺酸埃罗替尼
- 化合物 T0373L1
- 埃罗替尼甲磺酸盐
- 甲磺酸厄洛替尼
- 248594-19-6
- CP-358
- CP-358774;OSI-774;NSC 718781;R 1415
- Erlotinib mesylate
(CP-358774
- TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415
- Erlotinib (OSI-744) mesylate
- ERLOTINIB MESYLATE