2,5-二羟基-4-甲氧基二苯甲酮
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- CAS号:
- 52811-37-7
- 英文名:
- Cearoin
- 英文别名:
- Cearoin;2,5-Dihydroxy-4-methoxybenzophenone;(2,5-dihydroxy-4-methoxyphenyl)phenylmethanone;Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone;Methanone, (2,5-dihydroxy-4-methoxyphenyl)phenyl-
- 中文名:
- 2,5-二羟基-4-甲氧基二苯甲酮
- 中文别名:
- 2,5-二羟基-4-甲氧基二苯甲酮
- CBNumber:
- CB81469659
- 分子式:
- C14H12O4
- 分子量:
- 244.24
- MOL File:
- 52811-37-7.mol
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2,5-二羟基-4-甲氧基二苯甲酮化学性质
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熔点:
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188 °C(Solv: ethanol (64-17-5))
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沸点:
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443.8±45.0 °C(Predicted)
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密度:
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1.296±0.06 g/cm3(Predicted)
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储存条件:
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4°C, protect from light
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酸度系数(pKa):
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8.25±0.48(Predicted)
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2,5-二羟基-4-甲氧基二苯甲酮性质、用途与生产工艺
Cearoin 可从Dalbergia odorifera中分离，通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
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ERK
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ROS
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Autophagy
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Apoptosis
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Cearoin (10-80 μM) induces cell death in a dose-dependent manner.
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells.
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process.
Cell Viability Assay
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Cell Line:
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Human neuroblastoma SH-SY5Y cells
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Concentration:
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0, 1, 5, 10, 20, 40, or 80 μM
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Incubation Time:
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6 or 12 hours
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Result:
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Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.
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Western Blot Analysis
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Cell Line:
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Human neuroblastoma SH-SY5Y cells
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Concentration:
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0, 5, 10, 20, 40, or 80 μM
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Incubation Time:
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12 hours
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Result:
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Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner.
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2,5-二羟基-4-甲氧基二苯甲酮
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-N8418 | 2,5-二羟基-4-甲氧基二苯甲酮
Cearoin | 52811-37-7 | 1mg | 2500元 |
52811-37-7, 2,5-二羟基-4-甲氧基二苯甲酮 相关搜索:
- 其它酚类
- 2,5-二羟基-4-甲氧基二苯甲酮
- 52811-37-7
- 2,5-Dihydroxy-4-methoxybenzophenone
- Methanone, (2,5-dihydroxy-4-methoxyphenyl)phenyl-
- (2,5-dihydroxy-4-methoxyphenyl)phenylmethanone
- Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone
- Cearoin