替喹溴铵
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- CAS号:
- 71731-58-3
- 英文名:
- Tiquizium bromide
- 英文别名:
- Aspora;HS 902;Thiaton;HSR 902;Advaston;Gastirol;Tiquizium;TIQUIZIUM BROMIDE;Tiquizium bromide USP/EP/BP;2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, trans-
- 中文名:
- 替喹溴铵
- 中文别名:
- 替喹溴胺;替喹溴铵;(5R,9AR)-7-(二噻吩-2-基亚甲基)-5-甲基-1,2,3,4,6,8,9,9A-八氢喹嗪-5-溴化物;(5R,9aR)-7-(二噻吩-2-基亚甲基)-5-甲基-1,2,3,4,6,8,9,9a-八氢喹嗪-5-鎓溴化物
- CBNumber:
- CB8204996
- 分子式:
- C19H24BrNS2
- 分子量:
- 410.43
- MOL File:
- 71731-58-3.mol
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替喹溴铵化学性质
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熔点:
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278-281° (dec)
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储存条件:
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Refrigerator
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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替喹溴铵性质、用途与生产工艺
替喹溴铵作用机理主要是在毒蕈碱作用部位具有竞争性抗乙酰胆碱作用，对消化道等内脏平滑肌具有选择性的强大的解痉作用。对胃液分泌的抑制作用远比丁溴东莨菪碱强。
替喹溴铵适用于胃炎、胃和十二指肠溃疡、肠炎、过敏性结肠综合征和胆囊、胆道疾患引起的痉挛及运动功能亢进。
健康成人口服本品10mg，1.5h后原药在血清中的浓度达最高值，约10ng/ml，清除半衰期约1.4h。6h内有总排泄量的90%以上被排泄，24h内原药总排泄量是给药量的0.9%左右。尿中代谢物，除原药外主要有噻吩环-0-硫酸酯，也有微量噻吩环-0-葡萄糖醛酸苷。即本品在人体内的主要代谢途径是噻吩环的羟基化。
替喹溴铵
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71731-58-3, 替喹溴铵 相关搜索:
- Pharmaceutical raw material
- 医药原料
- C19H24NS2Br
- C19H24BrNS2
- C19H24NBrS2
- 替喹溴铵
- (5R,9AR)-7-(二噻吩-2-基亚甲基)-5-甲基-1,2,3,4,6,8,9,9A-八氢喹嗪-5-溴化物
- (5R,9aR)-7-(二噻吩-2-基亚甲基)-5-甲基-1,2,3,4,6,8,9,9a-八氢喹嗪-5-鎓溴化物
- 替喹溴胺
- 71731-58-3
- Tiquizium bromide USP/EP/BP
- 7-(dithiophen-2-ylmethylidene)-5-methyl-1,2,3,4,6,8,9,9a-octahydroquinolizin-5-ium bromide
- Thiaton
- HSR 902
- HS 902
- 2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, trans-
- 2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, (5R,9aR)-rel- (9CI)
- Tiquizium
- Gastirol
- Aspora
- Advaston
- (5r,9ar)-7-(dithiophen-2-ylmethylidene)-5-methyl-1,2,3,4,6,8,9,9a-octahydroquinolizin-5-ium bromide
- TIQUIZIUM BROMIDE