5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮
|
|
|
- CAS号:
- 484049-04-9
- 英文名:
- 5-(3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione
- 英文别名:
- 104868;AI3-61350;DPH >=98% (HPLC);5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin;5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione;5-(3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione;2,4-Imidazolidinedione, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-
- 中文名:
- 5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮
- 中文别名:
- DPH,C-ABL 激活剂;5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮
- CBNumber:
- CB82521130
- 分子式:
- C18H13FN4O2
- 分子量:
- 336.32
- MOL File:
- 484049-04-9.mol
|
|
|
5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮化学性质
-
密度:
-
1.45
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO: ≥10mg/mL
-
|
-
形态:
-
powder
-
|
-
酸度系数(pKa):
-
8.36±0.10(Predicted)
-
|
-
颜色:
-
white to tan
-
|
5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮性质、用途与生产工艺
DPH 是一种有效的，细胞渗透的 c-Abl 激活剂，在酶和细胞活动中，能够有效刺激 c-Abl 的活化。
DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation.
5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮
上下游产品信息
上游原料
下游产品
5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮
生产厂家
484049-04-9, 5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮 相关搜索:
- 药靶配体
- 有机中间体
- 蛋白酪氨酸激酶
- C18H13FN4O2
- DPH,C-ABL 激活剂
- 5-(3-(4-氟苯基)-1-苯基-1H-吡唑-4-基)咪唑烷-2,4-二酮
- 484049-04-9
- 104868
- 2,4-Imidazolidinedione, 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-
- DPH >=98% (HPLC)
- AI3-61350
- 5-[3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl]-2,4-imidazolidinedione
- 5-(1,3-diaryl-1H-pyrazol-4-yl)hydantoin
- 5-(3-(4-Fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)imidazolidine-2,4-dione