生长抑素肽类似物
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- CAS号:
- 174688-78-9
- 英文名:
- CH-275
- 英文别名:
- CH-275;CYS-LYS-PHE-PHE-D-TRP-IAMP-THR-PHE-THR-SER-CYS;[DES-ALA1, DES-GLY2, DES-ASN5, D-TRP8, IAMP9]SOMATOSTATIN-14;Cys-Lys-Phe-Phe-D-Trp-IAMp-Thr-Phe-Thr-Ser-Cys (Disulfide bridge Cys3-Cys14);L-Cysteine, L-cysteinyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-4-[[(1-methylethyl)amino]methyl]-L-phenylalanyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-, cyclic (1→11)-disulfide
- 中文名:
- 生长抑素肽类似物
- 中文别名:
- 生长抑素肽类似物
- CBNumber:
- CB8347170
- 分子式:
- C74H96N14O15S2
- 分子量:
- 1485.79
- MOL File:
- 174688-78-9.mol
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生长抑素肽类似物化学性质
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沸点:
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1732.9±65.0 °C(Predicted)
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密度:
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1.235±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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酸度系数(pKa):
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2.93±0.70(Predicted)
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形态:
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Powder
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水溶解性:
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Soluble to 0.30 mg/ml in water
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生长抑素肽类似物性质、用途与生产工艺
CH 275 是一种生长抑素的肽类似物，可以与生长抑素受体1 (sst1) 结合 (Ki=52 nM)。CH 275 是一种有效的选择性 sst1 激动剂 (IC50=30.9 nM)，刺激 sst3，sst4，sst2 和 sst5 的 IC50 值 分别为 345 nM，>1 μM，>10 μM 和 >10 μM。CH 275 可用于阿尔茨海默病的研究。
IC50: 30.9 nM; Ki: 52 nM (somatostatin receptor 1)IC50: 345 nM (somatostatin receptor 3)
CH275 (100 nM) activates neprilysin activity, wheras treatment with cyclo-SRIF can complete this activation in vitro in primary neuron-based cell culture system, a mixture of wildtype hippocampal, cortical and striatal neuron.
CH275 (osmotic pump administration; 56 μM; two weeks) decreases the level of neprilysin/SRIF in the
App
knock-in mice.CH275 directly injects into the Lacunosum molecular layer (Lmol) layer of 2-month-old
App
NL-G-F
mice for four months.
App
NL-G-F
mice begin to exhibit Aβ plaques at two months of age, but CH275 leads to robustly increased the expression of neprilysin in hippocampus which is paralleled by a clear reduction in Aβ plaque load in the same region, and without causing any toxic side effects.
生长抑素肽类似物
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-P1206 | CH 275 | | 1 mg | 2600元 |
| 2024/04/30 | HY-P1206 | CH 275 | | 5 mg | 8300元 |
174688-78-9, 生长抑素肽类似物 相关搜索:
- C74H96N14O15S2
- 生长抑素肽类似物
- 174688-78-9
- L-Cysteine, L-cysteinyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-D-tryptophyl-4-[[(1-methylethyl)amino]methyl]-L-phenylalanyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-, cyclic (1→11)-disulfide
- Cys-Lys-Phe-Phe-D-Trp-IAMp-Thr-Phe-Thr-Ser-Cys (Disulfide bridge Cys3-Cys14)
- CH-275
- [DES-ALA1, DES-GLY2, DES-ASN5, D-TRP8, IAMP9]SOMATOSTATIN-14
- CYS-LYS-PHE-PHE-D-TRP-IAMP-THR-PHE-THR-SER-CYS