6-溴靛玉红-3'-丙酮肟
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- CAS号:
- 667463-85-6
- 英文名:
- (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME
- 英文别名:
- CS-1611;BIO-ACETOXIME;GSK-3 INHIBITOR X;GSK3 Inhibitor IX2;BIA|||GSK-3 Inhibitor X;6-Bromoindirubin acetoxime;BIO-Acetoxime >=98% (HPLC);6-Bromoindirubin-3′-acetoxime;BIO-acetoxime(GSK-3 Inhibitor);BIO-acetoxime GSK3 Inhibitor IX2
- 中文名:
- 6-溴靛玉红-3'-丙酮肟
- 中文别名:
- 6-溴靛玉红-3'-丙酮肟;6-溴靛玉红-3'-丙酮肟;化合物BIO-ACETOXIME
- CBNumber:
- CB8818870
- 分子式:
- C18H12BrN3O3
- 分子量:
- 398.21
- MOL File:
- 667463-85-6.mol
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6-溴靛玉红-3'-丙酮肟化学性质
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密度:
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1.69±0.1 g/cm3(Predicted)
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储存条件:
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Keep in dark place,Sealed in dry,2-8°C
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溶解度:
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H2O: soluble2mg/mL (clear solution, warmed)
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形态:
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powder
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酸度系数(pKa):
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9.22±0.20(Predicted)
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颜色:
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dark red to purple
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6-溴靛玉红-3'-丙酮肟性质、用途与生产工艺
BIO-acetoxime (GSK-3 Inhibitor X) 是一种有效的双重GSK3α/β抑制剂,IC50为10 nM,选择性比 CDK5/p25,CDK2/cyclin A 和 CDK1/cyclin B高240倍以上。
Target | Value |
GSK-3α
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10 nM
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GSK-3β
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10 nM
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在人口腔上皮细胞中,BIO-acetoxime抑制病毒基因表达,并保护口腔上皮细胞免受HSV-1感染。在SY5Y-MYCN细胞中,BIO-acetoxime通过介导细胞凋亡大大降低KCN,KCNR,SY5Y,Kelly,和IMR32细胞的活性。在HEK 293T细胞中,BIO-acetoxime也能够通过抑制GSK3α/β活性,减少抗病毒先天免疫下游的IRF3活化。
BIO-acetoxime (BIA) shows anticonvulsant effects in the focal pilocarpine rat model at 0.5 mg/kg, and in 6-Hz fully kindled FVB/N mice at 0.5, 2.5, and 5 mg/kg via i.p. administration.
6-溴靛玉红-3'-丙酮肟
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-15356 | BIO-acetoxime | | 1 mg | 340元 |
2024/08/19 | HY-15356 | 6-溴靛玉红-3'-丙酮肟 BIO-acetoxime | 667463-85-6 | 5mg | 800元 |
667463-85-6, 6-溴靛玉红-3'-丙酮肟 相关搜索:
- Other enzyme inhibitors and activators
- 药靶配体
- 抑制剂
- 化合物BIO-ACETOXIME
- 6-溴靛玉红-3'-丙酮肟
- 6-溴靛玉红-3'-丙酮肟
- 667463-85-6
- BIA|||GSK-3 Inhibitor X
- BIO-Acetoxime >=98% (HPLC)
- 2H-Indol-2-one, 3-[(3E)-3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-, (3Z)-
- BIO-acetoxime (GSK-3 Inhibitor X)
- GSK3 INHIBITOR X6-BROMOINDIRUBIN-3'-ACETOXIME
- CS-1611
- BIO-acetoxime GSK3 Inhibitor IX2
- (2Z,3E)-3-(Acetoxyimino)-6'-bromo-[2,3'-biindolinylidene]-2'-one
- BIO-acetoxime(GSK-3 Inhibitor)
- GSK3 Inhibitor IX2
- 6-Bromoindirubin-3′-acetoxime
- 6-Bromoindirubin acetoxime
- (3Z)-3-[(3E)-3-[(Acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-Indol-2-one
- GSK-3 INHIBITOR X
- BIO-ACETOXIME
- (2'Z,3'E)-6-BROMOINDIRUBIN-3'-ACETOXIME