VU0357017
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- CAS号:
- 1135242-13-5
- 英文名:
- VU 0357017 hydrochloride
- 英文别名:
- CS-2319;VU0357017;CID 25010775;SID 56353039;VU0357017 HCI;ML071 hydrochloride;VU 0357017 hydrochloride;VU0357017 monohydrochloride;Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride;VU0-357017;VU 0357017;CID-25010775; VU-0357017 HYDROCHLORIDE; VU 0357017 HYDROCHLORIDE
- 中文名:
- VU0357017
- 中文别名:
- VU 0357017盐酸盐;盐酸 VU 0357017;优选]VU 0357017 HYDROCHLORIDE;4-((2-(2-甲基苯甲酰氨基)乙基)氨基)哌啶-1-羧酸乙酯盐酸盐
- CBNumber:
- CB92546794
- 分子式:
- C18H28ClN3O3
- 分子量:
- 369.9
- MOL File:
- 1135242-13-5.mol
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VU0357017化学性质
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储存条件:
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Inert atmosphere,2-8°C
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溶解度:
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DMSO: ≥10mg/mL
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形态:
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powder
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颜色:
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white to off-white
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VU0357017性质、用途与生产工艺
VU0357017 hydrochloride (CID-25010775)是一种强效的、中枢神经系统渗透性的高选择性 M1 激动剂，M1是 muscarinic acetylcholine receptors (mAChRs) 的一类亚型。VU0357017 hydrochloride 可在变构位点起作用以激活该受体，其EC50值为 477 nM 和 Ki值为 9.91 μM。
| Target | Value |
M1 mAChR
(Cell-free assay)
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477 nM(EC50)
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M1 mAChR
(Cell-free assay)
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9.91 μM(Ki)
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VU0357017 is selective for M
1
(K
i
=9.91 µM) over M
2
-M
5
mAChRs (K
i
=21.4, 55.3, 35.0, and 50.0 μM, respectively) in CHO cells.
VU0357017 (1 nM-100 μM) induces calcium release and ERK phosphorylation in a concentration-dependent manner in CHO cells.
VU0357017 (1-10 mg/kg, i.p.) reverses scopolamine-induced disruption of the contextual fear conditioning response.
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Animal Model:
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Male Sprague−Dawley rats (380-420 g) were pretreated with scopolamine
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Dosage:
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1, 3, 10 mg/kg
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Administration:
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A single i.p.
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Result:
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Produced a significant reversal of the scopolamine-induced deficits at a dose of 10 mg/kg.
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VU0357017
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-19752A | VU0357017
VU0357017 hydrochloride | 1135242-13-5 | 5mg | 700元 |
| 2024/04/30 | HY-19752A | VU0357017
VU0357017 hydrochloride | 1135242-13-5 | 10mM * 1mLin DMSO | 770元 |
1135242-13-5, VU0357017 相关搜索:
- Amines
- Positive allosteric modulator of muscarinic M1 receptors.
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- 药靶配体
- 抑制剂
- C18H27N3O3HCl
- 优选]VU 0357017 HYDROCHLORIDE
- 4-((2-(2-甲基苯甲酰氨基)乙基)氨基)哌啶-1-羧酸乙酯盐酸盐
- VU 0357017盐酸盐
- 盐酸 VU 0357017
- 1135242-13-5
- Muscarinic acetylcholine receptor,CID 25010775,VU 0357017,muscarinic,Inhibitor,inhibit,VU-0357017 hydrochloride,VU0357017 hydrochloride,VU0357017,mAChR,VU-0357017,CID25010775,acetylcholine,Alzheimer’s,schizophrenia
- VU0357017 HCI
- CS-2319
- VU0-357017;VU 0357017;CID-25010775; VU-0357017 HYDROCHLORIDE; VU 0357017 HYDROCHLORIDE
- VU0357017
- VU0357017 monohydrochloride
- SID 56353039
- ML071 hydrochloride
- Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride
- CID 25010775
- 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride
- 4-[[2-[(2-Methylbenzoyl)aMino]ethyl]aMino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride
- VU 0357017 hydrochloride