F-AMidine
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- CAS号:
- 877617-45-3
- 英文名:
- F-AMidine
- 英文别名:
- F-AMidine;F amidine,Famidine;N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide;Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-
- 中文名:
- F-AMidine
- 中文别名:
- 化合物 T24054
- CBNumber:
- CB92558584
- 分子式:
- C14H19FN4O2
- 分子量:
- 294.32
- MOL File:
- 877617-45-3.mol
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F-AMidine化学性质
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密度:
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1.27±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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13.26±0.46(Predicted)
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F-AMidine性质、用途与生产工艺
用途
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently m
odifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3
with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).
F-AMidine
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877617-45-3, F-AMidine 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Aromatics
- Amines
- 化合物 T24054
- 877617-45-3
- Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-
- F amidine,Famidine
- N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide
- F-AMidine