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F-AMidine

F-AMidine Structure
F-AMidine structure
CAS No.
877617-45-3
Chemical Name:
F-AMidine
Synonyms
F-AMidine;F amidine,Famidine;N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide;Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-
CBNumber:
CB92558584
Molecular Formula:
C14H19FN4O2
Molecular Weight:
294.32
MDL Number:
MFCD28138492
MOL File:
877617-45-3.mol
Last updated:2023-05-04 17:34:43
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F-AMidine Properties

Density 1.27±0.1 g/cm3(Predicted)
pka 13.26±0.46(Predicted)

F-AMidine price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC F101250 F-Amidine 877617-45-3 2.5mg $185 2021-12-16 Buy
Product number Packaging Price Buy
F101250 2.5mg $185 Buy

F-AMidine Chemical Properties,Uses,Production

Uses

An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).

Definition

ChEBI: F-Amidine is a N-acylglycine.

F-AMidine Preparation Products And Raw materials

Raw materials

Preparation Products

F-AMidine Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55936 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
J & K SCIENTIFIC LTD. 76
Chemsky (shanghai) International Co.,Ltd 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
F-AMidine N-[(1S)-1-(AMinocarbonyl)-4-[(2-fluoro-1-iMinoethyl)aMino]butyl]benzaMide F amidine,Famidine Benzamide, N-[(1S)-1-(aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]- 877617-45-3 Amines Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals