DYNGO-4A
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- CAS号:
- 1256493-34-1
- 英文名:
- 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide
- 英文别名:
- o-4a;Dyng;Dyngo-49;Dyngo-4a;Hydroxy-Dynasore;3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide;3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide;3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide;3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide;3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
- 中文名:
- DYNGO-4A
- 中文别名:
- 化合物DYNGO-4A;DYNGO?4A,新型的动力抑制剂;HYDROXY DYNASORE游离;3-羟基-N′-((2,4,5-三羟基苯基)亚甲基)-2-萘酰肼;2-萘甲酸,3-羟基,2-[(2,4,5-三羟基苯基)亚甲基]酰肼
- CBNumber:
- CB92668283
- 分子式:
- C18H14N2O5
- 分子量:
- 338.31
- MOL File:
- 1256493-34-1.mol
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DYNGO-4A化学性质
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密度:
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1.45±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: >10mg/mL
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酸度系数(pKa):
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8.28±0.40(Predicted)
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形态:
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powder
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颜色:
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faint yellow to dark yellow
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DYNGO-4A性质、用途与生产工艺
Hydroxy Dynasore (Dyngo-4a) 是 Dynasore (HY-15304) 结构模拟类似物，是一种改进的，低细胞毒性和通用的 dynamin 抑制剂，针对大脑重组 dynamin I 和重组鼠 dynamin II 的 IC50 值分别为 0.38 μM 和 2.3μM。Hydroxy Dynasore 抑制 dynamin 依赖性转铁蛋白的内吞作用 (endocytosis) 的 IC50 为 5.7 μM。
Dynamin is a large GTPase enzyme that severs membrane‐bound clathrin‐coated vesicles.
Endocytosis internalizes portions of cells’ plasma membrane along with extracellular material, is fundamentally important in cell physiology.
Hydroxy Dynasore inhibits Dynamin I (Dyn I) activity with IC
50
values of 2.7 μM and 0.38 μM with or without 0.06% Tween‐80 in the GTPase assay.
Hydroxy Dynasore shows an IC
50
of 5.7 μM in clathrin‐mediated endocytosis (CME) assay for inhibition of Tfn‐A594 uptake in U2OS cells.
Hydroxy Dynasore shows IC
50
values of 0.38 μM and 1.1 μM in absence of Tween-80, and exhibits IC
50
values of 4.9 μM and 30.0 μM in presence of Tween-80, respectively. Hydroxy Dynasore is 2.1‐fold selective for DynI versus DynII from Sf21 cells] and DynII (recombinant protein from Sf21 cells) in this GTPase assay.
Hydroxy Dynasore prevents the uptake of BoNT/A-Hc in cultured hippocampal neurons and in motor nerve terminals.
Hydroxy Dynasore (1-100μM; 20 min prior to the addition of Alexa Fluor 488-BoNT/A-Hc) results in depolarization of Hippocampal neurons, it dose-dependently inhibits internalization of Alexa Fluor 488-BoNT/A-Hc with an IC
50
of 16.0 ± 1.2 μM.
Hydroxy Dynasore (intraperitoneal injection; 30 mg/kg; 1.5-2 h before BoNT/A injection) provides protection again BoNT/A-induced paralysis in the phrenic nerve-hemidiaphragm twitch model in CD-1 mice.
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Animal Model:
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CD-1 mice.
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Dosage:
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30 mg/kg
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Administration:
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Intraperitoneal injection; 1.5–2 h before BoNT/A injection
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Result:
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Protected BoNT/A-induced paralysis in vivo.
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DYNGO-4A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-13863 | Hydroxy-Dynasore | | 5 mg | 590元 |
| 2024/01/25 | HY-13863 | DYNGO-4A
Hydroxy-Dynasore | 1256493-34-1 | 10mM * 1mLin DMSO | 640元 |
1256493-34-1, DYNGO-4A 相关搜索:
- 药靶配体
- 标准品
- 2-萘甲酸,3-羟基,2-[(2,4,5-三羟基苯基)亚甲基]酰肼
- DYNGO?4A,新型的动力抑制剂
- 化合物DYNGO-4A
- 3-羟基-N′-((2,4,5-三羟基苯基)亚甲基)-2-萘酰肼
- HYDROXY DYNASORE游离
- 1256493-34-1
- 3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide
- inhibit,Hydroxy-Dynasore,vesicle,Dynamin,Hydroxy Dynasore,Neuron,clathrin‐coated,Inhibitor,Endocytosis,Dynamin,GTPase,HydroxyDynasore
- 3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide
- o-4a
- Dyng
- 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide
- Dyngo-4a
- Hydroxy-Dynasore
- 3-Hydroxy-N′-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide
- 3-Hydroxy-2-naphthalenecarboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide
- Dyngo-49
- 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide