盐酸尼索西汀
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- CAS号:
- 57754-86-6
- 英文名:
- NISOXETINE HYDROCHLORIDE
- 英文别名:
- LY-94,939;Nsc298819;NisoxetineHCl;NISOXETINE HYDROCHLORIDE;LY-94939; NSC298819; NISOXETINE HCL;4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride;NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE;(±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride;(+/-)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanaminehydrochloride;3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine hydrochloride
- 中文名:
- 盐酸尼索西汀
- 中文别名:
- 盐酸尼索西汀;3-(2-甲氧基苯氧基)-N-甲基-3-苯基丙-1-胺盐酸盐
- CBNumber:
- CB9267088
- 分子式:
- C17H22ClNO2
- 分子量:
- 307.82
- MOL File:
- 57754-86-6.mol
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盐酸尼索西汀化学性质
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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H2O: 20 mg/mL
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形态:
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solid
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颜色:
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white
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水溶解性:
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Soluble to 100 mM in water
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盐酸尼索西汀性质、用途与生产工艺
Nisoxetine hydrochloride 是一种有效的和选择性的去甲肾上腺素转运蛋白 (NET) 的抑制剂，Kd 值为 0.76 nM。Nisoxetine hydrochloride 是一种抗抑郁药和局部麻药，它可以阻断电压门控性钠通道。
Nisoxetine inhibits [
3
H]Nisoxetine binding to rat frontal cortical membranes with a K
i
of 1.4±0.1 nM.
Nisoxetine inhibits [
3
H]Noradrenaline uptake into rat frontal cortical synaptosomes with a K
i
of 2.1±0.3 nM.
Nisoxetine inhibits Na
+
currents with IC
50
s of 1.6 and 28.6 µM at the membrane potential of -70 and -100 mV, respectively.
Nisoxetine (0.6-2.2 µM; a single intrathecal injection) displays dose-dependent effects on spinal anesthesia in rats.
Nisoxetine (2.2 µM; a single intrathecal injection) shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively.
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Animal Model:
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Sprague-Dawley rats(290-340 g)
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Dosage:
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0.6, 1.2, 1.8, 2.2 µM
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Administration:
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A single intrathecal injection
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Result:
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With ED
50
s of 0.82 , 0.75 and 0.70 µM in motor function, proprioception, and nociception respectively.
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盐酸尼索西汀
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B1704A | Nisoxetine hydrochloride | | 1 mg | 300元 |
| 2024/01/25 | HY-B1704A | 盐酸尼索西汀
Nisoxetine hydrochloride | 57754-86-6 | 5mg | 800元 |
57754-86-6, 盐酸尼索西汀 相关搜索:
- Adrenoceptor
- 药靶配体
- 其它
- Potent and selective inhibitor of the norepinephrine transporter (Ki = 5.1 nM).
- C17H21NO2HCl
- 3-(2-甲氧基苯氧基)-N-甲基-3-苯基丙-1-胺盐酸盐
- 盐酸尼索西汀
- 57754-86-6
- noradrenaline,channels,Monoamine Transporter,uptake,anesthetic,Inhibitor,Nisoxetine hydrochloride,Na channels,sodium,Nisoxetine,local,NET,antidepressant,Na+ channels,depression,Sodium Channel,transporter,inhibit
- 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine hydrochloride
- LY-94939; NSC298819; NISOXETINE HCL
- 4-((2-Nitrophenyl)thio)-2H-oxete hydrochloride
- LY-94,939, (±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride
- (±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride
- Nsc298819
- NisoxetineHCl
- (+/-)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanaminehydrochloride
- NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE
- NISOXETINE HYDROCHLORIDE
- (+/-)-GAMMA-(2-METHOXYPHENOXY)-N-METHYL-BENZENEPROPANAMINE HYDROCHLORIDE
- LY-94,939