429653-73-6
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- CAS号:
- 429653-73-6
- 英文名:
- Y16
- 英文别名:
- Y16;Y16, >98%;Y16, 429653-73-6;Inhibitor,inhibit,Y-16,Y 16,Ras,Y16;4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione;4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione;3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-
- 中文名:
- 429653-73-6
- 中文别名:
- 化合物Y16;G蛋白偶联RHO GEFS抑制剂(Y16);4-(3-((3-甲基苄基)氧基)亚苄基)-1-苯基吡唑烷-3,5-二酮
- CBNumber:
- CB92735545
- 分子式:
- C24H20N2O3
- 分子量:
- 384.43
- MOL File:
- 429653-73-6.mol
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429653-73-6化学性质
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密度:
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1.273±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble5mg/mL, clear (warmed)
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酸度系数(pKa):
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8.84±0.20(Predicted)
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形态:
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powder
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颜色:
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, faint yellow to dark orange
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429653-73-6性质、用途与生产工艺
Y16是G蛋白偶联Rho GEFs抑制剂。它能阻止LARG和Rho的结合，Kd值为80 nM。
Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.
Cell Viability Assay
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Cell Line:
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NIH 3T3 cells
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Concentration:
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10 μΜ, 30 μΜ
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Incubation Time:
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24 hours
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Result:
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Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA.
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Western Blot Analysis
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Cell Line:
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NIH 3T3 cells
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Concentration:
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10 μΜ, 30 μΜ
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Incubation Time:
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24 hours
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Result:
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Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA.
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429653-73-6
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-12649 | Y16 | | 1 mg | 320元 |
| 2024/01/25 | HY-12649 | 429653-73-6
Y16 | 429653-73-6 | 5mg | 700元 |
429653-73-6, 429653-73-6 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 4-(3-((3-甲基苄基)氧基)亚苄基)-1-苯基吡唑烷-3,5-二酮
- 化合物Y16
- G蛋白偶联RHO GEFS抑制剂(Y16)
- 429653-73-6
- 4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione
- Inhibitor,inhibit,Y-16,Y 16,Ras,Y16
- 3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-
- Y16, >98%
- Y16, 429653-73-6
- 4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
- Y16