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1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
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- CAS号:
- 1424635-83-5
- 英文名:
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- 英文别名:
- TRULI;Lats-IN-1;Lats-IN-1(TRULI );inhibit,LatsIN1,YAP,Yes-associated protein,Lats IN 1,Inhibitor;N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;(Z)-N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide;1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- 中文名:
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
- 中文别名:
- 化合物LATS-IN-1;N-(3-苄基噻唑-2(3H)-亚基)-1H-吡咯并[2,3-B]吡啶-3-甲酰胺
- CBNumber:
- CB98123852
- 分子式:
- C18H14N4OS
- 分子量:
- 334.39
- MOL File:
- 1424635-83-5.mol
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1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-化学性质
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密度:
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1.36±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 83.33 mg/mL (249.20 mM)
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形态:
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A solid
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酸度系数(pKa):
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12.30±0.40(Predicted)
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颜色:
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White to light yellow
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1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-性质、用途与生产工艺
Lats-IN-1 是一种高效的,ATP 竞争性的 Lats1 和 Lats2 激酶抑制剂。Lats-IN-1 能促进有丝分裂后哺乳动物组织的 Yap 依赖性增殖。
The IC
50
for Lats-IN-1 increases with the ATP concentration.
Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC
50
of 510 nM.
Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids.
Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation.
Cell Proliferation Assay
Cell Line:
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MCF 10A cells
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Concentration:
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10 μM
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Incubation Time:
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24 hours
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Result:
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Decreased the phosphorylation of Yap at residue S127.
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1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-138489 | TRULI | | 1 mg | 685元 |
2024/08/19 | HY-138489 | 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- Lats-IN-1 | 1424635-83-5 | 5mg | 1800元 |
1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-
生产厂家
1424635-83-5, 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- 相关搜索:
- 有机化学
- 化合物LATS-IN-1
- N-(3-苄基噻唑-2(3H)-亚基)-1H-吡咯并[2,3-B]吡啶-3-甲酰胺
- 1424635-83-5
- inhibit,LatsIN1,YAP,Yes-associated protein,Lats IN 1,Inhibitor
- (Z)-N-(3-benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
- N-(3-Benzylthiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
- Lats-IN-1
- Lats-IN-1(TRULI )
- TRULI
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-