维生素 B12A
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- CAS号:
- 59461-30-2
- 英文名:
- hydroxocobalamin monohydrochloride
- 英文别名:
- Einecs 261-772-4;Vitamin B12a monohydrochloride;Hydroxocobalain onohydrochloride;hydroxocobalamin monohydrochloride;Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC);Cyanocobalamin Impurity 13 (Cyanocobalamin EP Impurity H Hydrochloride);Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride;Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1);Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride
- 中文名:
- 维生素 B12A
- 中文别名:
- 羟钴胺单盐酸盐;化合物 T13731;维生素 B12杂质13 (维生素 B12 EP 杂质H 盐酸盐)
- CBNumber:
- CB9927953
- 分子式:
- C62H89ClCoN13O15P
- 分子量:
- 1381.83
- MOL File:
- 59461-30-2.mol
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维生素 B12A化学性质
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储存条件:
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2-8°C
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溶解度:
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methanol: soluble10mg/mL at 20°C, clear, dark red
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维生素 B12A性质、用途与生产工艺
Hydroxocobalamin monohydrochloride (Vitamin B12a monohydrochloride) 是一种可注射的天然维生素 B12，具有良好的不良反应特征，可作为维生素 B12 缺乏症 (包括恶性贫血) 的膳食补充剂。
The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO
in vitro
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Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).
More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.
维生素 B12A
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B2209A | Hydroxocobalamin monohydrochloride | | 5 mg | 375元 |
| 2024/04/30 | HY-B2209A | 维生素 B12A
Hydroxocobalamin monohydrochloride | 59461-30-2 | 10mg | 600元 |
59461-30-2, 维生素 B12A 相关搜索:
- 维生素 B12杂质13 (维生素 B12 EP 杂质H 盐酸盐)
- 化合物 T13731
- 羟钴胺单盐酸盐
- 59461-30-2
- Cyanocobalamin Impurity 13 (Cyanocobalamin EP Impurity H Hydrochloride)
- Hydroxocobalain onohydrochloride
- Vitamin B12a hydrochloride >=96% (UV), >=96% (HPLC)
- Vitamin B12a monohydrochloride
- Cobinamide,Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with(5,6-dimethyl-1-a-D-ribofuranosyl-1H-benzimidazole-kN3), hydrochloride (1:1)
- Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride
- hydroxocobalamin monohydrochloride
- Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride
- Einecs 261-772-4